FlyBase Allele Report: Dmel\E(Pc)[NIG.7776R]

General Information

Symbol

Dmel\E(Pc)^NIG.7776R

Species

D. melanogaster

Name

FlyBase ID

FBal0243852

Feature type

allele

Associated gene

Dmel\E(Pc)

Associated Insertion(s)

Carried in Construct

P{NIG.7776R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Saj et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Saj et al., 2010)

Mutagen

in vitro construct

(Saj et al., 2010)

Progenitor genotype

Carried in construct

P{NIG.7776R}

Cytology

Description

UASt regulatory sequences drive expression of a E(Pc) hairpin interfering RNA (IR) construct.

(Saj et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-7776R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates acute myeloid leukemia

modeled by Hsap\HOXA9::Hsap\NUP98^WT.UAS

(Gavory et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(Pc)^NIG.7776R, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

E(Pc)^NIG.7776R, Scer\GAL4^ey.PH is an enhancer of increased size | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(Pc)^NIG.7776R, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

E(Pc)^NIG.7776R, Scer\GAL4^ey.PH is an enhancer of adult cuticle phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

E(Pc)^NIG.7776R, Scer\GAL4^ey.PH is an enhancer of adult head phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Other

Statement

Reference

E(Pc)^NIG.7776R, Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH has wing | ectopic phenotype

(Gavory et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Hsap\HOXA9::Hsap\NUP98^WT.UAS and E(Pc)^NIG.7776R under the control of Scer\GAL4^ey.PH leads to ectopic wing-like structures in the dorsal-anterior part of the eye.

(Gavory et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

7776R-1

P{NIG.7776R}1

7776R-2

P{NIG.7776R}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

E(Pc)^NIG.7776R

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close