FlyBase Allele Report: Dmel\Dronc[ΔA8]

General Information

Symbol

Dmel\Dronc^ΔA8

Species

D. melanogaster

Name

FlyBase ID

FBal0244156

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kondo et al., 2006)

Progenitor genotype

P{EPgy2}Dronc^EY08574

(Kondo et al., 2006)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the Nc gene.

(Kondo et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Williams et al., 2006)

decreased cell death

(Kondo et al., 2006)

lethal | embryonic stage | maternal effect | recessive

(Kondo et al., 2006)

lethal | pupal stage | recessive

(Kondo et al., 2006)

Phenotype Manifest In

dendrite

(Williams et al., 2006)

larval dorsal multidendritic neuron ddaC

(Williams et al., 2006)

wing

(Kondo et al., 2006)

Detailed Description

Statement

Reference

Less than 0.1% of homozygotes emerge as adult escapers (most homozygotes die as early pupae). The adult escapers have apparently normal morphology, except that their wings are opaque due to a failure of wing cells to undergo apoptosis.

Animals that are maternally and zygotically mutant for Nc are embryonic lethal, with almost complete absence of apoptosis.

γ-ray induced apoptosis (which is is seen in wild-type third larval instar wing discs after irradiation with 40Gy of γ-rays) is completely suppressed in Nc^ΔA8 homozygotes.

(Kondo et al., 2006)

In flies homozygous for Nc^ΔA8, the pruning of ddaC dendrites is suppressed and many branches are still present 14-18 hours after puparium formation.

(Williams et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is an enhancer of abnormal neuroanatomy | P-stage | somatic clone phenotype of Ca-β⁴⁸

(Kanamori et al., 2013)

Suppressor of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is a suppressor | somatic clone of increased cell death | third instar larval stage phenotype of p53^GMR.Ex

(Kondo et al., 2006)

Dronc^ΔA8/Dronc^ΔA8 is a suppressor of visible phenotype of hid^GMR.PG

(Kondo et al., 2006)

Dronc^ΔA8/Dronc^ΔA8 is a suppressor of increased cell death | third instar larval stage phenotype of hid^GMR.PG

(Kondo et al., 2006)

NOT Suppressor of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is a non-suppressor | somatic clone of visible phenotype of p53^GMR.Ex

(Kondo et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is an enhancer of larval multidendritic class IV neuron | P-stage | somatic clone phenotype of Ca-β⁴⁸

(Kanamori et al., 2013)

Dronc^ΔA8/Dronc^ΔA8 is an enhancer of dendrite | P-stage | somatic clone phenotype of Ca-β⁴⁸

(Kanamori et al., 2013)

Suppressor of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is a suppressor | somatic clone of eye disc phenotype of p53^GMR.Ex

(Kondo et al., 2006)

Dronc^ΔA8/Dronc^ΔA8 is a suppressor of wing disc phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh-Gal4, rpr^UAS.cUa

(Kondo et al., 2006)

Dronc^ΔA8/Dronc^ΔA8 is a suppressor of eye phenotype of hid^GMR.PG

(Kondo et al., 2006)

Dronc^ΔA8/Dronc^ΔA8 is a suppressor of eye disc phenotype of hid^GMR.PG

(Kondo et al., 2006)

NOT Suppressor of

Statement

Reference

Dronc^ΔA8/Dronc^ΔA8 is a non-suppressor | somatic clone of eye phenotype of p53^GMR.Ex

(Kondo et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction in adult eye size caused by expression of W^GMR.PG is suppressed if the eye is made homozygous for Nc^ΔA8 (using the eyFLP method).

The apoptosis posterior to the morphogenetic furrow that is induced by W^GMR.PG in third larval instar eye discs is completely suppressed in a Nc^ΔA8/Nc^ΔA8 background.

The increased apoptosis in the eye disc caused by expression of p53^GMR.Ex is suppressed in a Nc^ΔA8/Nc^ΔA8 background, but the reduction in adult eye size caused by p53^GMR.Ex is not suppressed if the eye is made homozygous for Nc^ΔA8 (using the eyFLP method).

The accelerated recovery from G[[2]] arrest which is seen in Ice^Δ2C8 wing discs after irradiation with 40Gy of γ-rays is suppressed if the animals are also homozygous for Nc^ΔA8.

(Kondo et al., 2006)

Xenogenetic Interactions

Statement

Reference

Co-expression of BacA\p35^Scer\UAS.cHa and rpr^Scer\UAS.cUa in the posterior compartment of the wing disc under the control of Scer\GAL4^hh-Gal4 induces dramatic tissue overgrowth. This tissue overgrowth is suppressed by Nc^ΔA8/Nc^ΔA8.

(Kondo et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dronc^ΔA8

(Schott et al., 2017)

Nc^ΔA8

dronc^AΔ8

(Kondo et al., 2009)

dronc^ΔA8

(Pop et al., 2020, Shinoda et al., 2019, Kanamori et al., 2013, Kondo et al., 2006, Williams et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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