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General Information
Symbol
Dmel\DroncΔA8
Species
D. melanogaster
Name
FlyBase ID
FBal0244156
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of the Nc gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Less than 0.1% of homozygotes emerge as adult escapers (most homozygotes die as early pupae). The adult escapers have apparently normal morphology, except that their wings are opaque due to a failure of wing cells to undergo apoptosis.

Animals that are maternally and zygotically mutant for Nc are embryonic lethal, with almost complete absence of apoptosis.

γ-ray induced apoptosis (which is is seen in wild-type third larval instar wing discs after irradiation with 40Gy of γ-rays) is completely suppressed in NcΔA8 homozygotes.

In flies homozygous for NcΔA8, the pruning of ddaC dendrites is suppressed and many branches are still present 14-18 hours after puparium formation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference

DroncΔA8/DroncΔA8 is a non-suppressor | somatic clone of visible phenotype of p53GMR.Ex

Phenotype Manifest In
Enhancer of
Suppressor of
NOT Suppressor of
Statement
Reference

DroncΔA8/DroncΔA8 is a non-suppressor | somatic clone of eye phenotype of p53GMR.Ex

Additional Comments
Genetic Interactions
Statement
Reference

The reduction in adult eye size caused by expression of WGMR.PG is suppressed if the eye is made homozygous for NcΔA8 (using the eyFLP method).

The apoptosis posterior to the morphogenetic furrow that is induced by WGMR.PG in third larval instar eye discs is completely suppressed in a NcΔA8/NcΔA8 background.

The increased apoptosis in the eye disc caused by expression of p53GMR.Ex is suppressed in a NcΔA8/NcΔA8 background, but the reduction in adult eye size caused by p53GMR.Ex is not suppressed if the eye is made homozygous for NcΔA8 (using the eyFLP method).

The accelerated recovery from G[[2]] arrest which is seen in IceΔ2C8 wing discs after irradiation with 40Gy of γ-rays is suppressed if the animals are also homozygous for NcΔA8.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35Scer\UAS.cHa and rprScer\UAS.cUa in the posterior compartment of the wing disc under the control of Scer\GAL4hh-Gal4 induces dramatic tissue overgrowth. This tissue overgrowth is suppressed by NcΔA8/NcΔA8.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)