FlyBase Allele Report: Dmel\kibra[del]

General Information

Symbol

Dmel\kibra^del

Species

D. melanogaster

Name

FlyBase ID

FBal0244407

Feature type

allele

Associated gene

Dmel\kibra

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Yu et al., 2010)

Mutagen

FLPase

(Yu et al., 2010)

Progenitor genotype

PBac{RB}Meltrin^e00483

(Yu et al., 2010)

P{XP}kibra^d05870

(Yu et al., 2010)

Cytology

Description

Recombination between the two progenitor insertions has deleted the sequence between them, resulting in a 27kb deletion that removes the kibra locus.

(Yu et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:14,697,166..14,723,765 [-]

Comment:

Deletion of kibra resulting from FLP-catalyzed recombination using the FRT-containing transposons PBac{RB}Meltrin^e00483 and P{XP}kibra^d05870.

(Yu et al., 2010, Yu et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | somatic clone

(Yu et al., 2010)

Phenotype Manifest In

eye | somatic clone

(Yu et al., 2010)

follicle cell | somatic clone

(Yu et al., 2010)

interommatidial bristle | somatic clone

(Ling et al., 2010)

ommatidium | somatic clone

(Yu et al., 2010)

oocyte nucleus | somatic clone

(Yu et al., 2010)

Detailed Description

Statement

Reference

Pupal retinae composed of homozygous kibra^del mutant cells show an increase in the number of interommatidial cells.

(Ling et al., 2010)

Homozygous clones in the posterior follicle cells result in mislocalisation of the oocyte nucleus as well as the formation of a multilayered follicular epithelium. The mutant follicle cells have smaller nuclei than wild-type follicle cells.

Homozygous clones induced using the eyFLP method result in animals with larger eyes than normal. The mosaic eyes show an over-representation of mutant over wild-type tissue and the mutant clones contain an average of 5.8 extra interommatidial cells per ommatidial cluster when examined in pupae.

(Yu et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

kibra^del has visible | somatic clone phenotype, enhanceable by ex^e1

(Yu et al., 2010)

kibra^del has visible | somatic clone phenotype, enhanceable by Mer⁴

(Yu et al., 2010)

Enhancer of

Statement

Reference

kibra^del is an enhancer of visible | somatic clone phenotype of Mer⁴

(Yu et al., 2010)

kibra^del is an enhancer of visible | somatic clone phenotype of ex^e1

(Yu et al., 2010)

NOT Enhancer of

Statement

Reference

kibra[+]/kibra^del is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

kibra[+]/kibra^del is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

kibra^del has interommatidial bristle | somatic clone phenotype, enhanceable by crb^82-04

(Ling et al., 2010)

kibra^del has eye | somatic clone phenotype, enhanceable by ex^e1

(Yu et al., 2010)

kibra^del has ommatidium | somatic clone phenotype, enhanceable by ex^e1

(Yu et al., 2010)

kibra^del has eye | somatic clone phenotype, enhanceable by Mer⁴

(Yu et al., 2010)

kibra^del has ommatidium | somatic clone phenotype, enhanceable by Mer⁴

(Yu et al., 2010)

Enhancer of

Statement

Reference

kibra^del is an enhancer of ommatidium | somatic clone phenotype of Mer⁴

(Yu et al., 2010)

kibra^del is an enhancer of eye | somatic clone phenotype of ex^e1

(Yu et al., 2010)

kibra^del is an enhancer of ommatidium | somatic clone phenotype of ex^e1

(Yu et al., 2010)

kibra^del is an enhancer of eye | somatic clone phenotype of Mer⁴

(Yu et al., 2010)

NOT Enhancer of

Statement

Reference

kibra[+]/kibra^del is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

kibra[+]/kibra^del is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of kibra^del.

(Zaessinger et al., 2015)

Pupal retinae composed of crb^82-04 kibra^del double mutant cells show a massive increase in the number of interommatidial cells.

(Ling et al., 2010)

The small eye phenotype caused by hpo^GMR.PW is not affected if the eyes are also homozygous for kibra^del.

ex^e1 ; kibra^del and Mer⁴ ; kibra^del double mutant clones in the eye show a more severe eye overgrowth phenotype and a greater number of interommatidial cells per ommatidium than is seen in either single mutant.

(Yu et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

kibra^del is rescued by Scer\GAL4^Act.PU/kibra^UASp.cYa

(Yu et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

600580

w^*; P{neoFRT}82B kibra^del/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kibra^del

(Guo et al., 2024, Zaessinger et al., 2015, Ling et al., 2010, Yu et al., 2010, Yu et al., 2010)

kibraDgr;

(Liu et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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