FlyBase Allele Report: Dmel\dsx[GAL4]

General Information

Symbol

Dmel\dsx^GAL4

Species

D. melanogaster

Name

FlyBase ID

FBal0244772

Feature type

allele

Associated gene

Dmel\dsx

Associated Insertion(s)

TI{GAL4}dsx^GAL4

Carried in Construct

Also Known As

dsx-Gal4, dsx^GAL4(1)

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

recombination

(Robinett et al., 2010)

I-SceI

(Robinett et al., 2010)

FLPase

(Robinett et al., 2010)

gene targeting by homologous recombination

(Robinett et al., 2010)

Progenitor genotype

Associated Insertion(s)

TI{GAL4}dsx^GAL4

Cytology

Description

Sequence encoding a GAL4 driver has been inserted immediately after the translational start codon of dsx in exon 2, which is common to male and female dsx mRNAs. This GAL4 coding sequence is terminated by a single stop codon. The two codons 3' of the GAL4 stop codon encode different amino acids than those normally found in dsx proteins, but otherwise the dsx sequences both 5' and 3' of the GAL4 insertion site are unaltered in the targeted chromosome. This allele is anticipated, barring internal re-initiation of translation, to be a null dsx allele.

(Robinett et al., 2010)

Allele components

Component

Use(s)

Inserted element

TI{GAL4}

promoter trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-fertile

(Robinett et al., 2010)

male semi-fertile

(Robinett et al., 2010)

Phenotype Manifest In

adult vaginal plate opening descending neuron vpoDN | ectopic | male limited (with dsx¹⁵)

(Kimura et al., 2015)

Detailed Description

Statement

Reference

dsx¹⁵/dsx^GAL4 mutant adult males have ectopic formation of usually female-specific pMN2 neurons; pMN2 neurons are still present in females of this genotype as normal.

(Kimura et al., 2015)

dsx^GAL4 produces classical dsx mutant morphological phenotypes when heterozygous with the null alleles dsx¹ or In(3LR)dsx³⁴.

dsx^GAL4 caused reduced fertility in both sexes.

(Robinett et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66674

w¹¹¹⁸; TI{GAL4}dsx^GAL4/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dsx^GAL4(1)

(Pan et al., 2012, Pan et al., 2011)

dsx^GAL4

(Zhou et al., 2021, Wu et al., 2019, Clough et al., 2014, Robinett et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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