FlyBase Allele Report: Dmel\kibra[UASp.cGa]

General Information

Symbol

Dmel\kibra^UASp.cGa

Species

D. melanogaster

Name

FlyBase ID

FBal0244966

Feature type

allele

Associated gene

Dmel\kibra

Associated Insertion(s)

Carried in Construct

P{UASp-kibra.G}

Key Links

Transgenic product class

cDNA

(Genevet et al., 2010)

wild_type

(Genevet et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Genevet et al., 2010)

wild_type

(Genevet et al., 2010)

Mutagen

in vitro construct

(Genevet et al., 2010)

Progenitor genotype

Carried in construct

P{UASp-kibra.G}

Cytology

Description

UASp regulatory sequences drive expression of kibra cDNA sequences.

(Genevet et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

kibra

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | somatic clone | third instar larval stage, with Scer\GAL4^Tub.PU

(Su et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^hh-Gal4

(Su et al., 2017)

increased cell death, with Scer\GAL4^GMR.PU

(Genevet et al., 2010)

Phenotype Manifest In

eye disc, with Scer\GAL4^GMR.PU

(Genevet et al., 2010)

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Tub.PU

(Su et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^hh-Gal4

(Su et al., 2017)

Detailed Description

Statement

Reference

Expression of kibra^{Scer\UAS.P\T.cGa} under the control of Scer\GAL4^hh-Gal4 leads to reduced size of the posterior wing disc compartment in third instar larvae and Scer\GAL4^tub.PU-driven expression in MARCM wing disc clones decreases their relative size compared to discs bearing control wild-type clones.

(Su et al., 2017)

Expression of kibra^{Scer\UAS.P\T.cGa} under the control of Scer\GAL4^GMR.PF induces apoptosis in third larval instar eye discs.

(Genevet et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^hh-Gal4, kibra^UASp.cGa has abnormal size | third instar larval stage phenotype, suppressible by Scer\GAL4^hh-Gal4/ex^KK100573

(Su et al., 2017)

Scer\GAL4^Tub.PU, kibra^UASp.cGa has abnormal size | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by ex^e1/ex^e1

(Su et al., 2017)

Scer\GAL4^GMR.PU, kibra^UASp.cGa has increased cell death phenotype, suppressible by hpo^5.1

(Genevet et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/kibra^UASp.cGa is a suppressor of abnormal size | third instar larval stage phenotype of Scer\GAL4^hh-Gal4, ex^KK100573

(Su et al., 2017)

Scer\GAL4^Tub.PU/kibra^UASp.cGa is a suppressor of abnormal size | somatic clone | third instar larval stage phenotype of ex^e1

(Su et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^hh-Gal4, kibra^UASp.cGa has wing disc | third instar larval stage phenotype, suppressible by Scer\GAL4^hh-Gal4/ex^KK100573

(Su et al., 2017)

Scer\GAL4^Tub.PU, kibra^UASp.cGa has wing disc | somatic clone | third instar larval stage phenotype, suppressible | somatic clone by ex^e1/ex^e1

(Su et al., 2017)

Scer\GAL4^GMR.PU, kibra^UASp.cGa has eye disc phenotype, suppressible by hpo^5.1

(Genevet et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/kibra^UASp.cGa is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^hh-Gal4, ex^KK100573

(Su et al., 2017)

Scer\GAL4^Tub.PU/kibra^UASp.cGa is a suppressor of wing disc | somatic clone | third instar larval stage phenotype of ex^e1

(Su et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The enlarged posterior wing disc compartment characteristic for third instar larvae expressing ex^KK100573 under the control of Scer\GAL4^hh-Gal4 is suppressed by co-expression of kibra^{Scer\UAS.P\T.cGa}, which on its own leads to reduced wing disc size.

The increased relative size of somatic MARCM clones mutant for ex^e1 in third instar larval wing discs (as compared to wild-type clones in control discs) is suppressed by expression of kibra^{Scer\UAS.P\T.cGa} in the mutant clones (driven by Scer\GAL4^tub.PU), which on its own produces clones of reduced size.

(Su et al., 2017)

hpo^5.1 suppresses the ectopic apoptosis in the eye discs which is induced by expression of kibra^{Scer\UAS.P\T.cGa} under the control of Scer\GAL4^GMR.PF.

(Genevet et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kibra^{Scer\UAS.P\T.cGa}

kibra^UASp.cGa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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