FlyBase Allele Report: Dmel\ex[KK100573]

General Information

Symbol

Dmel\ex^KK100573

Species

D. melanogaster

Name

FlyBase ID

FBal0258770

Feature type

allele

Associated gene

Dmel\ex

Associated Insertion(s)

Carried in Construct

P{KK100573}

Also Known As

UAS-ex-i, UAS-ex RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100573}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100573

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^nub-AC-62

(Su et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^hh-Gal4

(Su et al., 2017)

Phenotype Manifest In

wing blade, with Scer\GAL4^nub-AC-62

(Su et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^hh-Gal4

(Su et al., 2017)

Detailed Description

Statement

Reference

Expression of ex^KK100573 leads to enlarged posterior wing disc compartment in third instar larvae (with the Scer\GAL4^hh-Gal4 driver) and increased size of adult wing blade (with the Scer\GAL4^nub-AC-62 driver).

(Su et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^hh-Gal4, ex^KK100573 has abnormal size | third instar larval stage phenotype, suppressible by Scer\GAL4^hh-Gal4/kibra^UASp.cGa

(Su et al., 2017)

Scer\GAL4^nub-AC-62, ex^KK100573 has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^nub-AC-62/kibra^UASp.cYa

(Su et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/ex^KK100573 is a suppressor of abnormal size | third instar larval stage phenotype of Scer\GAL4^hh-Gal4, kibra^UASp.cGa

(Su et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^hh-Gal4, ex^KK100573 has wing disc | third instar larval stage phenotype, suppressible by Scer\GAL4^hh-Gal4/kibra^UASp.cGa

(Su et al., 2017)

Scer\GAL4^nub-AC-62, ex^KK100573 has wing blade phenotype, suppressible by Scer\GAL4^nub-AC-62/kibra^UASp.cYa

(Su et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^hh-Gal4/ex^KK100573 is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^hh-Gal4, kibra^UASp.cGa

(Su et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The enlarged posterior wing disc compartment in third instar larvae (with the Scer\GAL4^hh-Gal4 driver) as well as the increased size of adult wing blade (with the Scer\GAL4^nub-AC-62 driver) characteristic for animals expressing ex^KK100573 is suppressed by co-expression of either kibra^{Scer\UAS.P\T.cGa} or kibra^{Scer\UAS.P\T.cYa}, respectively, which on their own lead to reduced wing disc and adult wing sizes.

(Su et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109281

P{KK100573}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ex^KK100573

ex^RNAi

(Deng et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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