FlyBase Allele Report: Agam\fru[MC.UAS]

General Information

Symbol

Agam\fru^MC.UAS

Species

A. gambiae

Name

FlyBase ID

FBal0245118

Feature type

allele

Associated gene

Agam\fru

Associated Insertion(s)

Carried in Construct

P{UAS-Agam\fru.MC}

Also Known As

UAS-Agfru^MC

Transgenic product class

wild_type

(Gailey et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Gailey et al., 2006)

Mutagen

in vitro construct

(Billeter et al., 2006, Gailey et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Agam\fru.MC}

Cytology

Description

UASt regulatory sequences drive expression of sequences coding for the MC isoform of Agam\fru.

(Gailey et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Agam\fru

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^fru.16

(Billeter et al., 2006)

Phenotype Manifest In

serotonergic neuron, with Scer\GAL4^fru.16

(Billeter et al., 2006)

Detailed Description

Statement

Reference

Wild-type females expressing Agam\fru^MC.Scer\UAS under the control of Scer\GAL4^fru.16 develop on average three ectopic 'male' serotonergic neurons, both ventrally and dorsally, sending projections into the abdominal nerve trunk. Ectopic serotonergic terminals innervated the female internal reproductive organs, mostly the calyx of the ovaries but also, more rarely, the uterus and the base of the spermathecae. These serotonergic terminals are never present in virgin or fertilised wild-type females. The ectopic serotonergic neurons and their associated terminalia are analogous to those innervating the male reproductive organs.

(Billeter et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Agam\fru^MC.UAS/Scer\GAL4^fru.16 is a suppressor of abnormal neuroanatomy phenotype of fru³/fru^ΔC

(Billeter et al., 2006)

Agam\fru^MC.UAS/Scer\GAL4^fru.16 is a suppressor of semi-fertile phenotype of fru³

(Billeter et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

Agam\fru^MC.UAS/Scer\GAL4^fru.16 is a suppressor of muscle cell of muscle of Lawrence phenotype of fru³/fru^ΔC

(Billeter et al., 2006)

Agam\fru^MC.UAS/Scer\GAL4^fru.16 is a suppressor of serotonergic neuron phenotype of fru³/fru^ΔC

(Billeter et al., 2006)

Agam\fru^MC.UAS/Scer\GAL4^fru.16 is a suppressor of muscle cell of muscle of Lawrence phenotype of fru³

(Gailey et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Agam\fru^MC.Scer\UAS under the control of Scer\GAL4^fru.16, in a fru³/fru^ΔC background (in which fru[MA] and fru[MB], but not the fru[MC] transcript are present) increases the percentage of fertile males from 33 to 65% of wild-type levels.

Expression of Agam\fru^MC.Scer\UAS under the control of Scer\GAL4^fru.16, in a fru³/fru^ΔC background (in which fru[MA] and fru[MB], but not the fru[MC] transcript are present) rescues the formation of the muscle of Lawrence in the male.

Expression of Agam\fru^MC.Scer\UAS under the control of Scer\GAL4^fru.16, in a fru³/fru³ background suppresses the loss of both male-specific serotonergic abdominal giant neuron clusters.

(Billeter et al., 2006)

Expression of Agam\fru^MC.Scer\UAS under the control of Scer\GAL4^fru.16 is sufficient to suppress the Muscle of Lawrence(MOL)-less phenotype of fru³ mutant males and to induce formation of a MOL-like muscle in females.

(Gailey et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Agam\fru^MC.Scer\UAS

Agam\fru^MC.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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