Open Close
General Information
Symbol
Agam\fruMC.UAS
Species
A. gambiae
Name
FlyBase ID
FBal0245118
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-AgfruMC
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of sequences coding for the MC isoform of Agam\fru.

UASt regulatory sequences drive expression of sequences coding for the MC isoform of Agam\fru.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wild-type females expressing Agam\fruMC.Scer\UAS under the control of Scer\GAL4fru.16 develop on average three ectopic 'male' serotonergic neurons, both ventrally and dorsally, sending projections into the abdominal nerve trunk. Ectopic serotonergic terminals innervated the female internal reproductive organs, mostly the calyx of the ovaries but also, more rarely, the uterus and the base of the spermathecae. These serotonergic terminals are never present in virgin or fertilised wild-type females. The ectopic serotonergic neurons and their associated terminalia are analogous to those innervating the male reproductive organs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Agam\fruMC.Scer\UAS under the control of Scer\GAL4fru.16, in a fru3/fruΔC background (in which fru[MA] and fru[MB], but not the fru[MC] transcript are present) increases the percentage of fertile males from 33 to 65% of wild-type levels.

Expression of Agam\fruMC.Scer\UAS under the control of Scer\GAL4fru.16, in a fru3/fruΔC background (in which fru[MA] and fru[MB], but not the fru[MC] transcript are present) rescues the formation of the muscle of Lawrence in the male.

Expression of Agam\fruMC.Scer\UAS under the control of Scer\GAL4fru.16, in a fru3/fru3 background suppresses the loss of both male-specific serotonergic abdominal giant neuron clusters.

Expression of Agam\fruMC.Scer\UAS under the control of Scer\GAL4fru.16 is sufficient to suppress the Muscle of Lawrence(MOL)-less phenotype of fru3 mutant males and to induce formation of a MOL-like muscle in females.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Agam\fruMC.Scer\UAS
Agam\fruMC.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)