FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RhoLXA12
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General Information
Symbol
Dmel\RhoLXA12
Species
D. melanogaster
Name
FlyBase ID
FBal0245177
Feature type
allele
Associated gene
Dmel\RhoL
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Siekhaus et al., 2010)
Progenitor genotype
P{GawB}RhoL10-161
(Siekhaus et al., 2010)
Cytology
Description

Imprecise excision of the progenitor insertion.

(Siekhaus et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RhoLXA12 mutant embryos show much reduced movement of haemocytes into the tail at stage 11 and 12, and 44% of embryos show no haemocyte migration into the tail region. In these mutant embryos haemocytes move up to the tail region and produce protrusions towards it, but fail to enter. Haemocyte migration along the anterior ventral nerve cord and dorsal vessel appears normal, and haemocytes show normal lamellipodia and filopodia formation.

      RhoLXA12/Df(3R)by416 mutant embryos show much reduced movement of haemocytes into the tail. Migration along the dorsal vessel is normal in these animals.

      (Siekhaus et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      RhoLXA12 is rescued by RhoLUAS.cSa/Scer\GAL48-163

      (Siekhaus et al., 2010)
      Comments

      Expression of RhoLScer\UAS.cSa under the control of Scer\GAL48-169 in RhoLXA12 mutant embryos rescues the migration of haemocytes into the tail region of the embryo and along the posterior ventral nerve cord.

      (Siekhaus et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RhoLXA12
      rhoLXA12
      (Siekhaus et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)