FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PI4KBKD.βTub85D
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General Information
Symbol
Hsap\PI4KBKD.βTub85D
Species
H. sapiens
Name
FlyBase ID
FBal0245295
Feature type
allele
Associated gene
Hsap\PI4KB
Associated Insertion(s)
Carried in Construct
P{βTub85D-hPI4K.KD}
Key Links
Transgenic product class
missense_variant
(Polevoy et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Polevoy et al., 2009)
Mutagen
in vitro construct
(Polevoy et al., 2009)
Progenitor genotype
Carried in construct
P{βTub85D-hPI4K.KD}
Cytology
Description

Expression of a modified form of Hsap\PI4KB carrying the mutation D656A, under the control of the spermatocyte-specific βTub85D promoter.

(Polevoy et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
βTub85D
Encoded product / tool
Hsap\PI4KB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Hsap\PI4KBKD.βTub85D is a non-suppressor of male sterile phenotype of Df(3L)7C/fwd3

      (Polevoy et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hsap\PI4KBKD.βTub85D is a suppressor | partially of spermatid phenotype of Df(3L)7C/fwd3

      (Polevoy et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PI4KBKD.βTub85D partially rescues the cytokinesis defects of fwd3/Df(3L)7C mutant males. Male infertility is not rescued in these animals.

      (Polevoy et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\PI4KBKD.βTub85D
      Name Synonyms
      Secondary FlyBase IDs
        References (1)