FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CkIIαJF01436
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General Information
Symbol
Dmel\CkIIαJF01436
Species
D. melanogaster
Name
FlyBase ID
FBal0245701
Feature type
allele
Associated gene
Dmel\CkIIα
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01436}
Also Known As
CkIIα-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01436}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01436
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  schizophrenia
      CEA with slgAUAS.D
      (Zwarts et al., 2017)
      CEA with slgAUAS.E
      (Zwarts et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT exacerbate  schizophrenia
      modeled by slgAUAS.A
      (Zwarts et al., 2017)
      modeled by slgAUAS.B
      (Zwarts et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of CkIIαJF01436 under the combined control of Scer\GAL4P2.4.Pdf and Gal80[ts] (induced by temperature shift from 19[o] to 25[o]C at eclosion) leads to a significant decrease in aggressive behavior, as compared to controls.

      (Zwarts et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adulthood-only co-expression of either slgAUAS.D or slgAUAS.E in combination with CkIIαJF01436, under the combined control of Scer\GAL4P2.4.Pdf and Gal80[ts] and induced by temperature shift from 19[o] to 25[o]C at eclosion, leads to a significant increase in aggressive behavior compared to controls, and contrasts with the decreased aggressive behavior of CkIIαJF01436 or CkIIαGL00003 single expressions.

      (Zwarts et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CkIIαJF01436
      Name Synonyms
      Secondary FlyBase IDs
        References (6)