Under constant darkness conditions, flies expressing dom^JF01502 under the control of either Scer\GAL4^tim.PE or Scer\GAL4^P2.4.Pdf (in combination with Dicer-2, for more efficient RNAi) frequently lose circadian rhythmicity; in the Scer\GAL4^tim.PE background, circadian periods also become longer. Upon expression under the combined control of Scer\GAL4^tim.PE and Scer\GAL80^Pdf.PS (in combination with Dicer-2, for more efficient RNAi) periods become longer despite of no changes in rhythmicity, as compared to controls; longer periods are also observed when this expression is restricted to adulthood, but not to development (using Gal80[ts] for the temporal control of expression).

Under LD cycles, flies expressing dom^JF01502 under the control of Scer\GAL4^tim.PE (in combination with Dicer-2, for more efficient RNAi), do not show the expected morning peak of anticipatory activity.

The expression of dom^JF01502 under the control of Scer\GAL4^tim.PE or Scer\GAL4^P2.4.Pdf does not lead to obvious defects in the brain structure, but leads to a decrease in the number of lLNv neurons. In the Scer\GAL4^P2.4.Pdf settings, the lLNv neurons also have shorter dorsal projections. Expression under the control of Scer\GAL4^tim.PE leads to defects in the maintenance, but not development of sLNv neuron (i.e. no change in number in larvae, but a decrease in pupae and adults). When the Scer\GAL4^tim.PE-regulated expression is restricted to adulthood (by Gal80[ts]), there are no changes in the number or dorsal projections of sLNvs.

Expression of dom^JF01502 results in: slightly rough eye phenotype (with either the Scer\GAL4^ey.PH or the Scer\GAL4^GMR.PF driver) or occasional ectopic veins in anterior wing (with Scer\GAL4^nub.PK). Scer\GAL4^Act5C.PI-driven expression is lethal while no overt adult phenotype is observed with Scer\GAL4^en.PU.

Expression of dom^JF01502 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of dom^JF01502 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls. The total dendritic length is increased in ddaD neurons.

Expression of dom^JF01502 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC, v'ada and vdaB neurons. The total number of dendritic branches is also reduced in ddaC neurons.

76% of flies co-expressing dom^JF01502 and dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 show wing nicking.