FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)gd108
Open Close
General Information
Symbol
Dmel\l(2)gd108
Species
D. melanogaster
Name
FlyBase ID
FBal0246240
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
Carried in Construct
Also Known As
lgd08
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gallagher and Knoblich, 2006)
Mutagen
ethyl methanesulfonate
(Gallagher and Knoblich, 2006)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Gallagher and Knoblich, 2006)

Amino acid replacement: Q595term.

(Gallagher and Knoblich, 2006)

The premature stop codon is predicted to result in a truncated protein that lacks the C2 domain.

(Gallagher and Knoblich, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:11,108,992..11,108,992 [+]
Nucleotide change:

C11108992T

Reported nucleotide change:

C?T

Amino acid change:

Q595term | l(2)gd1-PA; Q595term | l(2)gd1-PB

Reported amino acid change:

Q595term

(Gallagher and Knoblich, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      l(2)gd108 mutant flies show missing and abnormal external sensory organs, consisting of four sockets but no hair cells. Mutant heads are significantly enlarged.

      l(2)gd108 mutant clones show loss of hairs and multiple sockets.

      The size and morphology of the early endosomes in sensory organ precursor cells from l(2)gd108 mutant clones is disrupted. The early endosomes are increased in size compared to controls. The morphology of late endosomes, recycling endosomes, and the exocyst are unchanged.

      (Gallagher and Knoblich, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      2L08
      (Gallagher and Knoblich, 2006)
      l(2)gd108
      lgd08
      (Bäumers et al., 2019, Troost et al., 2012, Gallagher and Knoblich, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)