FlyBase Allele Report: Dmel\Nep2[EP3549]

General Information

Symbol

Dmel\Nep2^EP3549

Species

D. melanogaster

Name

FlyBase ID

FBal0246262

Feature type

allele

Associated gene

Dmel\Nep2

Associated Insertion(s)

P{EP}Nep2^EP3549

Carried in Construct

Also Known As

EP(3)3549^nep2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}Nep2^EP3549

Cytology

Description

P{EP}Nep2^EP3549 is inserted 93 bp upstream of Nep2 and is shown to drive transcription of the Nep2 gene.

(Finelli et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:4,731,948..4,731,948 [-]

(Sofola-Adesakin et al., 2016, Bland et al., 2009, Cao et al., 2008, Finelli et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008, Finelli et al., 2004)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{3Q42.Aβ42.Tag:SS(rPENK)}

(Sofola-Adesakin et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression using Scer\GAL4^ey.PU does not induce a rough eye phenotype.

(Cao et al., 2008)

Scer\GAL4^ey.PU-mediated expression of Nep2^EP3549 does not cause any eye defects.

Scer\GAL4^elav-C155-mediated expression of Nep2^EP3549 does not show any effect on life span.

(Finelli et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Nep2^EP3549, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Finelli et al., 2004)

Other

Statement

Reference

Hsap\MAPT^UAS.cWa, Nep2^EP3549, Scer\GAL4^ey.PU has lethal phenotype

(Cao et al., 2008)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Nep2^EP3549, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Suppressor of

Statement

Reference

Nep2^EP3549/Scer\GAL4^ey.PU is a suppressor of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008, Finelli et al., 2004)

NOT Suppressor of

Statement

Reference

Nep2^EP3549, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Cao et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Nep2^EP3549 using Scer\GAL4^ey.PU suppresses the Hsap\APP[Aβ42.GMR] rough eye phenotype.

Co-expression of Nep2^EP3549 suppresses the reduced life span seen in Hsap\APP^{Aβ42.Scer\UAS}, Scer\GAL4^elav-C155 flies.

(Finelli et al., 2004)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Nep2^EP3549

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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