FlyBase Gene Report: Dmel\Nep2

General Information

Symbol

Dmel\Nep2

Species

D. melanogaster

Name

Neprilysin 2

Annotation Symbol

CG9761

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027570

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

Gene Summary

Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706). (UniProt, A0A0B4K692)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dNEP2

Key Links

Genomic Location

Cytogenetic map

82D2-82D2

Sequence location

3R:4,719,458..4,731,878 [-]

Recombination map

3-47.1

RefSeq locus

NT_033777 REGION:4719458..4731878

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables endopeptidase activity

inferred from direct assay

(Thomas et al., 2005)

enables metalloendopeptidase activity

inferred from mutant phenotype

(Finelli et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000199753

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR018497

(InterPro Project Members, 2004-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR024079

(InterPro Project Members, 2004-)

inferred from sequence model

(Sitnik et al., 2014)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in proteolysis

inferred from direct assay

(Thomas et al., 2005)

involved_in sperm competition

inferred from mutant phenotype

(Sitnik et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN000199753

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from sequence model

(Sitnik et al., 2014)

inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR008753, InterPro:IPR018497

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Thomas et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Sitnik et al., 2014)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000199753

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NEPRILYSINS

Protein Family (UniProt)

Belongs to the peptidase M13 family. (A0A0B4K692)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

metalloendopeptidase activity

Summaries

Gene Group (FlyBase)

NEPRILYSINS -: Neprilysins belong to the MEROPS M13 family of metalloproteases. The majority of proteins of this family are integral membrane proteins located at the cell surface, acting as ectoenzymes that catalyze the hydrolysis of extracellular signaling peptides. They contain all four of the conserved motifs defined as important for catalytic activity. (Adapted from FBrf0214506 and FBrf0239474.)

Protein Function (UniProtKB)

(UniProt, A0A0B4K692)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nep2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K692)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nep2-RA

FBtr0078891

NM_079503

2763

763

Nep2-RB

FBtr0305133

NM_001259985

2796

774

Nep2-RC

FBtr0333922

NM_001275331

3103

763

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nep2-PA

FBpp0078531

86.8

763

6.72

FBpp0293663

88.1

774

6.12

FBpp0306050

86.8

763

6.72

Q9XZ01

NP_001262260

AGB95643

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

763 aa isoforms: Nep2-PA, Nep2-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

N-glycosylated.

The soluble form is probably produced by proteolytic cleavage.

(UniProt, A0A0B4K692)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A0A0B4K692

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nep2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nep2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.09

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

longitudinal trunk visceral muscle primordium

(Bland et al., 2007)

embryonic stage 13 -- 16

larval foregut atrium

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic stage 17

embryonic/larval Malpighian tubule

(Bland et al., 2007)

adult stage

Malpighian tubule Type II cell

(Thomas et al., 2005)

spermatogenesis & adult stage | male

testis | restricted

(Thomas et al., 2005)

tail cyst cell

(Thomas et al., 2005)

oogenesis stage S9 -- S10

centripetal follicle cell

(Manning et al., 2017)

egg chamber | restricted

(Manning et al., 2017)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Iijima-Ando et al., 2008)

Additional Descriptive Data

In adult testis, Nep2 is apparent in tail cyst cells of elongating cysts and in tail cyst cells surrounding the waste bags.

(Thomas et al., 2005)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Malpighian tubule Type II cell

(Thomas et al., 2005)

spermatogenesis & adult stage | male

testis | restricted

(Thomas et al., 2005)

tail cyst cell

(Thomas et al., 2005)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

In adult testis, Nep2 is apparent in tail cyst cells of elongating cysts and in tail cyst cells surrounding the waste bags.

(Thomas et al., 2005)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Thomas et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

Reporter: Mi{PT-GFSTF.2}Nep2^{MI01118-GFSTF.2}

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S9 -- S10

border follicle cell

(Manning et al., 2017)

centripetal follicle cell

(Manning et al., 2017)

Reporter: PBac{806.LOX-SVS-2}Nep2^CPTI003993

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

ellipsoid body

(Knowles-Barley, 2011.8.24)

fan-shaped body

Comment: strong expression in top layer of fan-shaped body

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nep2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nep2

View exonic expression by tissue for Dmel\Nep2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40588/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027570

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9761

Flygut - An atlas of the Drosophila adult midgut

FBgn0027570

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Nep2

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nep2

Transgenic constructs containing regulatory region of Nep2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6142

(Ryder, 2004.4.26)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

Nep2^GD13223

viable, with Scer\GAL4^pnr-MD237

Nep2^GD13223

viable, with Scer\GAL4^tin.CΔ4

Nep2^GD13223

Sterility

Allele

female semi-sterile

Nep2^Δ

female semi-sterile, with Scer\GAL4^nSyb.PS

Nep2^GD13223

female semi-sterile, with Scer\GAL4^Send1.4kb

Nep2^GD13223

female semi-sterile, with Scer\GAL4^Tub.PU

Nep2^GD13223

male fertile

Nep2^Δ

male fertile, with Scer\GAL4^Tub.PU

Nep2^GD13223

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\ECE1

6 of 14

Yes

Hsap\ECEL1

6 of 14

Yes

Hsap\EEF1AKMT4-ECE2

6 of 14

Yes

Hsap\MME

6 of 14

Yes

Hsap\MMEL1

6 of 14

Yes

Hsap\ECE2

5 of 14

Hsap\PHEX

5 of 14

Yes

Hsap\KEL

4 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Ece1

6 of 14

Yes

Rnor\Ece2

6 of 14

Yes

Rnor\Ecel1

6 of 14

Yes

Rnor\Mmel1

6 of 14

Yes

Rnor\Mme

5 of 14

Rnor\Phex

5 of 14

Yes

Rnor\Kel

4 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Ece1

6 of 14

Yes

Mmus\Gm49333

6 of 14

Yes

Mmus\Mme

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Mmus\Kel

4 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\ece2

4 of 13

Yes

Xtro\ecel1

4 of 13

Yes

Xtro\mme

4 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (6)

Drer\LOC100332538

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Drer\kel

3 of 14

Caenorhabditis elegans (Nematode, roundworm) (26)

Cele\nep-1

6 of 14

Yes

Cele\nep-2

6 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Cele\nep-19

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP001791

12 of 12

Yes

4 of 12

4 of 12

4 of 12

3 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nep2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

6 of 13

6 of 13

6 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

goe

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

neurodegenerative disease, MME-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

ECEL1; endothelin converting enzyme like 1

model of distal arthrogryposis type 5D

IEA

(FlyBase, 2019-)

ECE1; endothelin converting enzyme 1

model of essential hypertension

IEA

(FlyBase, 2019-)

MME; membrane metalloendopeptidase

model of cerebellar ataxia type 43

IEA

(FlyBase, 2019-)

model of Charcot-Marie-Tooth disease axonal type 2T

IEA

(FlyBase, 2019-)

PHEX; phosphate regulating endopeptidase X-linked

model of X-linked hypophosphatemic rickets

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Nep2^KG05754

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Nep2^EP3549

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008, Finelli et al., 2004)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{3Q42.Aβ42.Tag:SS(rPENK)}

(Sofola-Adesakin et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ECE1; endothelin converting enzyme 1

6 of 14

600423

essential hypertension

ECEL1; endothelin converting enzyme like 1

6 of 14

605896

ARTHROGRYPOSIS, DISTAL, TYPE 5D; DA5D

distal arthrogryposis type 5D

EEF1AKMT4-ECE2; EEF1AKMT4-ECE2 readthrough

6 of 14

MME; membrane metalloendopeptidase

6 of 14

MEMBRANE METALLOENDOPEPTIDASE; MME

MMEL1; membrane metalloendopeptidase like 1

6 of 14

618104

ECE2; endothelin converting enzyme 2

5 of 14

610145

PHEX; phosphate regulating endopeptidase X-linked

5 of 14

300550

HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; XLHRD

X-linked hypophosphatemic rickets

KEL; Kell metallo-endopeptidase (Kell blood group)

4 of 14

613883

BLOOD GROUP--KELL SYSTEM; KEL

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65805

DroID - A comprehensive database of gene and protein interactions.

FBgn0027570

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.1

Cytogenetic map

82D2-82D2

Sequence location

3R:4,719,458..4,731,878 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82D2-82D2

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.1

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

61902

y¹ v¹; P{TRiP.HMJ23457}attP40

37121

y¹ w^*; Mi{MIC}Nep2^MI01118

76625

y¹ w^*; Mi{Trojan-GAL4.2}Nep2^{MI01118-TG4.2}

14456

y¹ w^67c23; P{SUPor-P}Nep2^KG05754 ry⁵⁰⁶

60161

y¹ w^*; Mi{PT-GFSTF.2}Nep2^{MI01118-GFSTF.2}/TM6C, Sb¹ Tb¹

Kyoto

115464

w¹¹¹⁸; PBac{806.LOX-SVS-2}Nep2^CPTI003993

NIG-Fly

9761R-1

P{NIG.9761R}1

9761R-3

P{NIG.9761R}3

HMJ23457

y¹ v¹; P{TRiP.HMJ23457}attP40/CyO

VDRC

v102584

P{KK112073}VIE-260B

v23172

w¹¹¹⁸; P{GD13223}v23172

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (187)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH07643

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027570

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027570

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Thomas et al., 2005)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Nep2 BcDNA:GH07643

(Thomas et al., 2001)

Source for identity of: Nep2 CG9761

(Shirras, 2001.8.23)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:GH07643

CG9761

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sekiya et al., 2017, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Philipps et al., 2004, Turner et al., 2001, Coates et al., 2000)

DmNEP2

(Bland et al., 2008)

NEP2

(Lang et al., 2013, Iijima-Ando et al., 2008)

dNEP2

(Sekiya et al., 2017, Isaac et al., 2003, Shirras, 2001.8.23, Thomas et al., 2001)

nep2

(Sofola-Adesakin et al., 2016, Meyer et al., 2011, Cao et al., 2008, Finelli et al., 2004)

Name Synonyms

Neprilysin 2

(Preat and Goguel, 2016, Meyer et al., 2011, Bland et al., 2009, Thomas et al., 2001)

neprilysin 2

(Finelli et al., 2004)

neprilysin-2

(Finelli et al., 2004)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40588

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K692

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A0A0B4K692

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K692

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40588/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027570

FlyMine - An integrated database for Drosophila genomics

FBgn0027570

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9761

MARRVEL_MODEL - MARRVEL (model organism gene)

40588

Linkouts

BioGRID - A database of protein and genetic interactions.

65805

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027570

DroID - A comprehensive database of gene and protein interactions.

FBgn0027570

DRSC - Results frm RNAi screens

FBgn0027570

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nep2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027570

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9761

Flygut - An atlas of the Drosophila adult midgut

FBgn0027570

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0027570

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (74)

The following external sites may use different assemblies or annotations than FlyBase.

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