FlyBase Gene Report: Dmel\goe

General Information

Symbol

Dmel\goe

Species

D. melanogaster

Name

gone early

Annotation Symbol

CG9634

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027528

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

gone early (goe) encodes a non-peptidase homolog of Neprilysin (M13) family metalloendopeptidases. It is expressed in various EGF (epidermal growth factor) ligand-producing cells and can attenuate EGFR signaling. The roles of the procut of goe include regulation of primordial germ cell differentiation and germline stem cell formation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

15A3-15A5

Sequence location

X:16,727,304..16,751,910 [-]

Recombination map

1-55

RefSeq locus

NC_004354 REGION:16727304..16751910

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

NOT enables peptidase activity

inferred from key residues

(Meyer et al., 2021, Matsuoka et al., 2014)

inferred from key residues with MEROPS:M13.UNW

(GO curators, 2012-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of stem cell differentiation

inferred from mutant phenotype

(Matsuoka et al., 2014)

involved_in oogenesis

inferred from mutant phenotype

(Matsuoka et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR008753

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Matsuoka et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000199753

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NEPRILYSIN-LIKE METALLOENDOPEPTIDASES

Protein Family (UniProt)

Belongs to the peptidase M13 family. (Q9XZ14)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NEPRILYSIN-LIKE METALLOENDOPEPTIDASES -: The Neprilysin-like metallopeptidases belong to the M13 family of metalloproteases. They show significant similarity to vertebrate and Drosophila Neprilysins but lack one or more of the conserved motifs important for catalytic activity, indicating they are likely inactive peptidases. (Adapted from FBrf0239474.)

Protein Function (UniProtKB)

Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, maintaining them in an undifferentiated proliferative state.

(UniProt, Q9XZ14)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\goe for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9XZ14)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

goe-RA

FBtr0074359

NM_132932

3661

879

goe-RB

FBtr0343363

NM_001298420

3646

874

goe-RC

FBtr0343364

NM_001298421

3281

879

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

goe-PA

FBpp0074133

100.1

879

6.43

FBpp0310020

99.6

874

6.43

FBpp0310021

100.1

879

6.43

Q9XZ14

NP_001285350

AHN59820

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

879 aa isoforms: goe-PA, goe-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\goe using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.58

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5 -- 6

mesectoderm | subset

(Kearney et al., 2004)

embryonic stage 7 -- 8

mesectoderm anlage | subset

(Kearney et al., 2004)

embryonic stage 9 -- 12

ventral midline of embryo

(Matsuoka et al., 2014)

tracheal primordium

(Matsuoka et al., 2014)

midline primordium

(Kearney et al., 2004)

embryonic stage 12

organism | segmentally repeated

(Matsuoka et al., 2014)

embryonic stage 13 -- 16

midline glial cell

(Kearney et al., 2004)

lineage MNB primary interneuron

(Kearney et al., 2004)

larval MP1 neuron

(Kearney et al., 2004)

third instar larval stage

ovary

(Matsuoka et al., 2014)

female germline cell

(Matsuoka et al., 2014)

wing disc | ubiquitous

(Matsuoka et al., 2014)

Additional Descriptive Data

goe is expressed in a germline-specific manner in late third instar larval ovaries where it is localized to a membrane compartment at the interface between germ cells. Outside of ovaries, it is expressed the ventral midline, tracheal placodes, and at the anterior-most row of each segment in embryos. It is also expressed uniformly in wing discs.

(Matsuoka et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Matsuoka et al., 2014)

Expression Deduced from Reporters

Reporter: P{goe-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

female germline cell

(Matsuoka et al., 2014)

ovary

(Matsuoka et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\goe in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\goe

View exonic expression by tissue for Dmel\goe

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32660/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027528

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027528

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027528

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9634

Flygut - An atlas of the Drosophila adult midgut

FBgn0027528

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of goe

Transgenic constructs containing regulatory region of goe

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)CRIMIC-CR71096

(Gene Disruption Project members, 2018-)

Inferred from location ( 28 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

goe^GD1174

viable, with Scer\GAL4^pnr-MD237

goe^GD1174

Sterility

Allele

fertile

Other Phenotypes

Allele

visible, with Scer\GAL4^nub.PU

Phenotype manifest in

Allele

cystoblast | third instar larval stage, with Scer\GAL4^{VP16.nanos.UTR}

goe^UAS.cMa

female germline cell | third instar larval stage, with Scer\GAL4^{VP16.nanos.UTR}

goe^UAS.cMa

female germline cell | third instar larval stage (with goe^5-11)

goe³³¹

female germline cell | third instar larval stage (with goe³³¹)

goe^5-11

female germline cyst | third instar larval stage, with Scer\GAL4^{VP16.nanos.UTR}

goe^UAS.cMa

wing, with Scer\GAL4^nub.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\ECE1

4 of 14

Yes

Hsap\EEF1AKMT4-ECE2

4 of 14

Yes

Hsap\KEL

4 of 14

Yes

Hsap\MMEL1

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Ece1

4 of 14

Yes

Rnor\Ece2

4 of 14

Yes

Rnor\Kel

4 of 14

Yes

Rnor\Mmel1

4 of 14

Yes

Rnor\Ecel1

3 of 14

Rnor\Phex

3 of 14

Rnor\Mme

2 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Ece1

4 of 14

Yes

Mmus\Gm49333

4 of 14

Yes

Mmus\Kel

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\ece2

3 of 13

Yes

Xtro\mme

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (6)

Drer\ece1

3 of 14

Yes

Drer\ece2b

3 of 14

Yes

Drer\kel

3 of 14

Yes

Drer\LOC100332538

3 of 14

Yes

Drer\mmel1

3 of 14

Yes

Drer\phex

3 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (26)

Cele\nep-1

4 of 14

Yes

Cele\nep-2

4 of 14

Yes

Cele\nep-5

4 of 14

Yes

Cele\nep-12

4 of 14

Yes

Cele\nep-22

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nep-19

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP007796

3 of 12

Yes

Agam\AgaP_AGAP009791

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:goe. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ECE1; endothelin converting enzyme 1

model of essential hypertension

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ECE1; endothelin converting enzyme 1

4 of 14

600423

essential hypertension

EEF1AKMT4-ECE2; EEF1AKMT4-ECE2 readthrough

4 of 14

KEL; Kell metallo-endopeptidase (Kell blood group)

4 of 14

613883

BLOOD GROUP--KELL SYSTEM; KEL

MMEL1; membrane metalloendopeptidase like 1

4 of 14

618104

ECE2; endothelin converting enzyme 2

3 of 14

610145

ECEL1; endothelin converting enzyme like 1

3 of 14

605896

ARTHROGRYPOSIS, DISTAL, TYPE 5D; DA5D

distal arthrogryposis type 5D

MME; membrane metalloendopeptidase

3 of 14

MEMBRANE METALLOENDOPEPTIDASE; MME

PHEX; phosphate regulating endopeptidase X-linked

3 of 14

300550

HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; XLHRD

X-linked hypophosphatemic rickets

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

goe

enhanceable

aos

(Matsuoka et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0027528

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-55

Cytogenetic map

15A3-15A5

Sequence location

X:16,727,304..16,751,910 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

15A3-15A5

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-55

(FlyBase, 2016)

1-56.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18600

w¹¹¹⁸ PBac{WH}goe^f02939

41853

y¹ v¹; P{TRiP.GL01281}attP2

58344

y¹ v¹; P{TRiP.HMJ22475}attP40

77546

w¹¹¹⁸ PBac{IT.GAL4}goe^0317-G4

58518

y¹ w^* Mi{MIC}goe^MI12441

15368

y¹ w^67c23 P{EPgy2}goe^EY01697

77826

y¹ w^* Mi{Trojan-GAL4.1}goe^{MI12441-TG4.1}

Korea

11142

P{EP}goe^G9684

NIG-Fly

HMJ22475

y¹ v¹; P{TRiP.HMJ22475}attP40/CyO

VDRC

v104344

P{KK104608}VIE-260B

v42820

w¹¹¹⁸; P{GD1174}v42820

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD21405

Other clones

DPiM_LD21405

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027528

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027528

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Matsuoka et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: goe CG9634

(Matsuoka et al., 2014)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BcDNA:LD21405

CG9634

(Meyer et al., 2021, Meyer et al., 2018.7.18, Franz et al., 2017, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Matsuoka et al., 2014, Sitnik et al., 2014, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Pan and Zhang, 2009, Bland et al., 2008, Turner et al., 2008, Shigenobu et al., 2006, FlyBase, 1992-)

Nepl2

(Meyer et al., 2018.7.18)

goe

(Meyer et al., 2021, Hall et al., 2019, Meyer et al., 2018.7.18, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Matsuoka et al., 2014)

Name Synonyms

Neprilysin-like 2

(Meyer et al., 2018.7.18)

gone early

(Matsuoka et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32660

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9XZ14

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9XZ14

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JFT2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9XZ14

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32660/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027528

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027528

FlyMine - An integrated database for Drosophila genomics

FBgn0027528

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9634

MARRVEL_MODEL - MARRVEL (model organism gene)

32660

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027528

DroID - A comprehensive database of gene and protein interactions.

FBgn0027528

DRSC - Results frm RNAi screens

FBgn0027528

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027528

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027528

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9634

Flygut - An atlas of the Drosophila adult midgut

FBgn0027528

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0027528

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (49)

The following external sites may use different assemblies or annotations than FlyBase.

-1.58

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