FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sraS215A.UASp
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General Information
Symbol
Dmel\sraS215A.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0246309
Feature type
allele
Associated gene
Dmel\sra
Associated Insertion(s)
Carried in Construct
P{UASp-sra.S215A}
Key Links
Transgenic product class
missense_variant
(Takeo et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Takeo et al., 2010)
Mutagen
in vitro construct
(Takeo et al., 2010)
Progenitor genotype
Carried in construct
P{UASp-sra.S215A}
Cytology
Description

UASp regulatory sequences drive expression of a S215A mutant form of sra.

(Takeo et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
sra
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mis-expression of sraS215A.Scer\UAS.P\T in germ-line cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in low levels of egg hatching. The majority of eggs have a single spindle in which the chromosome configuration appears to be arrested at anaphase I.

      The defective egg hatching phenotype resulting from the mis-expression of sraS215A.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 is strongly enhanced by sraKO heterozygosity.

      (Takeo et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      sraS215A.UASp/Scer\GAL4VP16.nanos.UTR fails to rescue sraKO

      (Takeo et al., 2010)
      Comments

      sraS215A.Scer\UAS.P\T driven by Scer\GAL4nos.UTR.T:Hsim\VP16 fails to restore female fertility or meiotic phenotype in sraKO homozygotes.

      (Takeo et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sraS215A.Scer\UAS.P\T
      sraS215A.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (1)