FB2026_02 , released June 18, 2026
Allele: Dmel\ATP7EY07895
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General Information
Symbol
Dmel\ATP7EY07895
Species
D. melanogaster
Name
FlyBase ID
FBal0246349
Feature type
allele
Associated gene
Dmel\ATP7
Associated Insertion(s)
P{EPgy2}ATP7EY07895
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
    Nature of the Allele
    Allele class

    gain of function allele

    (Cao et al., 2008)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}ATP7EY07895
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Adults expressing ATP7EY07895 under the control of Scer\GAL4elav.PU show reduced mobility in a climbing assay.

        (Xiao et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        ATP7[+]/ATP7EY07895 is an enhancer of eye phenotype of Hsap\APPAβ42.GMR.Tag:SS(rPENK)

        (Cao et al., 2008)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        ATP7EY07895/Scer\GAL4GMR.PU is a non-suppressor of phenotype of Zzzz\CAG99.UAS.Tag:MYC,Tag:FLAG

        (Xiao et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Co-expression of ATP7EY07895 ameliorates the climbing defects and reduced lifespan of adults expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU.

        (Lang et al., 2013)

        Co-expression of ATP7EY07895 partially suppresses loss of eye pigmentation and progressive loss of rhabdomeres seen in flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU.

        Co-expression of ATP7EY07895 suppresses the aggregation of Hsap\HTTQ93.ex1p.Scer\UAS protein seen in the brains of flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU.

        Co-expression of ATP7EY07895 has no effect on the reduction in lifespan seen in flies expressing Hsap\HTTM8V.H82A.Q127.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU at 29[o]C.

        Co-expression of ATP7EY07895 has no effect on the loss of eye pigmentation seen in flies expressing Hsap\HTTM8V.H82A.Q127.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU at 29[o]C.

        (Xiao et al., 2013)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        ATP7EY07895
        (Cao et al., 2008)
        DmATP7 OE
        (Xiao et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)