FlyBase Allele Report: Dmel\Rheb[1.1.UAS]

General Information

Symbol

Dmel\Rheb^1.1.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0246849

Feature type

allele

Associated gene

Dmel\Rheb

Associated Insertion(s)

Carried in Construct

P{UAS-Rheb.1.1}

Key Links

Transgenic product class

wild_type

(Khurana et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Khurana et al., 2006)

Mutagen

in vitro construct

(Khurana et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Rheb.1.1}

Cytology

Description

UAS regulatory sequences drive expression of Rheb.

(Khurana et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rheb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^{S202A.T205A.UAS}

(Steinhilb et al., 2007)

modeled by Hsap\MAPT^{T231A.S235A.UAS}

(Steinhilb et al., 2007)

modeled by Hsap\MAPT^{S396A.S404A.UAS}

(Steinhilb et al., 2007)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Steinhilb et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult brain, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Detailed Description

Statement

Reference

Expression of Rheb^1.1.Scer\UAS under the control of Scer\GAL4^elav.PLu induces cell cycle activation and neurodegeneration.

(Khurana et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^{T231A.S235A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^{S396A.S404A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^{T231A.S235A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Rheb^1.1.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^{S396A.S404A.UAS}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG} suppresses the Scer\GAL4^GMR.PF>Hsap\MAPT^{S396A.S404A.Scer\UAS}-induced rough eye phenotype.

Co-expression of Rheb^1.1.Scer\UAS enhances the Scer\GAL4^GMR.PF>Hsap\MAPT^{T231A.S235A.Scer\UAS}-induced rough eye phenotype.

Co-expression of Rheb^1.1.Scer\UAS enhances the Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}-induced rough eye phenotype.

Co-expression of Rheb^1.1.Scer\UAS enhances the Scer\GAL4^GMR.PF>Hsap\MAPT^Scer\UAS.cWa-induced rough eye phenotype.

(Steinhilb et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rheb^1.1.Scer\UAS

Rheb^1.1.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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