FlyBase Allele Report: Hsap\MAPT[S202A.T205A.UAS]

General Information

Symbol

Hsap\MAPT^{S202A.T205A.UAS}

Species

H. sapiens

Name

FlyBase ID

FBal0284070

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{UAS-tau.S202A.T205A}

Key Links

Transgenic product class

missense_variant

(Steinhilb et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Steinhilb et al., 2007)

Mutagen

in vitro construct

(Steinhilb et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-tau.S202A.T205A}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\MAPT carrying amino acid substitutions S202A and T205A.

(Steinhilb et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Papanikolopoulou and Skoulakis, 2015, Steinhilb et al., 2007)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of tauopathy

is exacerbated by CycE^UAS.cLa

(Steinhilb et al., 2007)

is ameliorated by BacA\p35^UAS.cHa

(Steinhilb et al., 2007)

is exacerbated by Rheb^1.1.UAS

(Steinhilb et al., 2007)

is ameliorated by gig^{ΔAkt-P.UAS.Tag:FLAG}

(Steinhilb et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Detailed Description

Statement

Reference

Expression of Hsap\MAPT^{S202A.T205A.Scer\UAS} in the retina under the control of Scer\GAL4^GMR.PF results in a moderately rough eye.

(Steinhilb et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Rheb^1.1.UAS, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by CycE^UAS.cLa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Suppressed by

Statement

Reference

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by gig^{ΔAkt-P.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Rheb^1.1.UAS, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by CycE^UAS.cLa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Suppressed by

Statement

Reference

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by gig^{ΔAkt-P.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Hsap\MAPT^{S202A.T205A.UAS}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Steinhilb et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of BacA\p35^Scer\UAS.cHa suppresses the rough eye phenotype of Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}.

Co-expression of CycE^Scer\UAS.cLa strongly enhances the toxicity of Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}.

Co-expression of dap^{Scer\UAS.cdNa} and Rbf^Scer\UAS.cDa substantially suppresses the Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}-induced eye phenotype.

Co-expression of Rheb^1.1.Scer\UAS enhances the Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}-induced rough eye phenotype.

Co-expression of gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG} suppresses the Scer\GAL4^GMR.PF>Hsap\MAPT^{S202A.T205A.Scer\UAS}-induced rough eye phenotype.

(Steinhilb et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MAPT^{S202A.T205A.Scer\UAS}

Hsap\MAPT^{S202A.T205A.UAS}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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