FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\porinUAS.Tag:FLAG
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General Information
Symbol
Dmel\porinUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0247215
Feature type
allele
Associated gene
Dmel\porin
Associated Insertion(s)
Carried in Construct
P{UAS-porin.FLAG}
Key Links
Transgenic product class
wild_type
(Park et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Park et al., 2010)
Mutagen
in vitro construct
(Park et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-porin.FLAG}
Cytology
Description

UASt regulatory sequences drive expression of porin which is tagged at the N-terminal end with Tag:FLAG.

(Park et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
porin
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR show defects in mitochondrial morphology in the indirect flight muscles, with smaller than normal mitochondria being seen between the muscle fibers.

      (Park et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of either MarfScer\UAS.T:Zzzz\FLAG or opa1-likeScer\UAS.T:Zzzz\FLAG significantly rescues the defects in mitochondrial morphology in the indirect flight muscles which is seen in adults expressing porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR.

      Flies expressing porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Mef2.PR in a Drp12/+ background show defects in mitochondrial morphology in the indirect flight muscles, with smaller or almost completely abolished mitochondria.

      (Park et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      porinUAS.Tag:FLAG/Scer\GAL4Tub.PU rescues porinA2

      (Park et al., 2010)
      Comments

      Expression of porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4tub.PU rescues the defects in climbing and flight ability that are seen in porinA2 flies 20 days after eclosion.

      Expression of porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4tub.PU rescues the sterility of porinA2 homozygous males.

      Expression of porinScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4tub.PU significantly rescues the defects in mitochondrial morphology in the indirect flight muscles that are seen in porinA2 homozygotes.

      (Park et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      porinScer\UAS.T:Zzzz\FLAG
      porinUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)