FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\heph2-d1
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General Information
Symbol
Dmel\heph2-d1
Species
D. melanogaster
Name
FlyBase ID
FBal0247322
Feature type
allele
Associated gene
Dmel\heph
Associated Insertion(s)
P{?PZ}heph2-d1
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Robida et al., 2010)

hypomorphic allele - molecular evidence

(Robida et al., 2010)
Mutagen
P-element activity
(Robida et al., 2010)
Progenitor genotype
P{PZ}heph2
(Robida et al., 2010)
Associated Insertion(s)
P{?PZ}heph2-d1
Cytology
Description

Incomplete excision of the progenitor insertion P{PZ}heph2.

(Robida et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3R:31,938,181..31,938,182 [-]
Comment:

The heph2-d1 allele was genereated by incomplete excision of the P{PZ}heph2 element so relative to the reference sequence there is an insertion of unspecified length at this location.

(Robida et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The testis tips of heph2-dl mutants exhibit a high frequency of defects such as minor swelling and the formation of knobs in the tip region. Testes show a lack of individualized non-motile sperm. Many of the cysts of elongated spermatids appear to be less tightly bundled and exhibit localised unraveling compared to controls.

      (Robida et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      heph2-d1
      heph2-dl
      (Robida et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)