FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlg1SA.UAS.GFP
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General Information
Symbol
Dmel\dlg1SA.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0247450
Feature type
allele
Associated gene
Dmel\dlg1
Associated Insertion(s)
Carried in Construct
P{UAS-dlg1.SA.GFP}
Key Links
Transgenic product class
missense_variant
(Zhang et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Zhang et al., 2007)
Mutagen
in vitro construct
(Zhang et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-dlg1.SA.GFP}
Cytology
Description

UASt regulatory sequences drive expression of the dlg1 S97 cDNA which has been mutated to contain the S797A amino acid replacement.

(Zhang et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dlg1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of dlg1SA.Scer\UAS.T:Avic\GFP partially suppresses the decrease in the number of boutons at the neuromuscular junction which is seen in animals expressing par-1Scer\UAS.cSa under the control of Scer\GAL4Mhc.PW.

      The defects in the frequency and amplitude of the miniature excitatory junctional current which are caused by expression of par-1Scer\UAS.cSa under the control of Scer\GAL4Mhc.PW are suppressed by co-expression of dlg1SA.Scer\UAS.T:Avic\GFP. The double mutant animals show a slight increase in the amplitude of the evoked excitatory junctional current compared to wild-type controls, and the quantal content is also higher than normal.

      (Zhang et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Mhc.PW/dlg1SA.UAS.GFP rescues dlg17

      (Zhang et al., 2007)
      Comments

      Expression of dlg1SA.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4Mhc.PW rescues the decrease in the number of boutons at the neuromuscular junction which is seen in dlg17 homozygotes.

      (Zhang et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dlg1SA.Scer\UAS.T:Avic\GFP
      dlg1SA.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)