FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BubR1A1204K.PR
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General Information
Symbol
Dmel\BubR1A1204K.PR
Species
D. melanogaster
Name
FlyBase ID
FBal0247987
Feature type
allele
Associated gene
Dmel\BubR1
Associated Insertion(s)
Carried in Construct
P{BubR1-KD.A1204K}
Key Links
Transgenic product class
missense_variant
(Rahmani et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rahmani et al., 2009)
Mutagen
in vitro construct
(Rahmani et al., 2009)
Progenitor genotype
Carried in construct
P{BubR1-KD.A1204K}
Cytology
Description

Amino acid replacement: A1204K.

(Rahmani et al., 2009)

This transgene carries the BubR1 coding region with an amino acid mutation within the kinase subdomain II, under the control of the BubR1 promoter.

(Rahmani et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
BubR1
Encoded product / tool
BubR1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BubR1A1204K.PR brains treated with colchicine exhibit a 2.5-fold increase in mitotic density, similar to wild-type. Premature sister chromatid separation rose sevenfold after 60 minutes in colchicine.

      (Rahmani et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      BubR1A1204K.PR-mad2G6595 double mutants are not delayed in prometaphase (as in BubR1A1204K.PR single mutants) but instead show a rapid mitotic transit time and early onset of CycB degradation (as in mad2G6595 single mutants). Double mutants are uniformly larval/pupal lethal and double mutant brains exhibit a lower mitotic density with neuroblast aneuploidy and abnormal anaphases more frequent than in both single mutants.

      BubR1A1204K.PR cnnHK21 double mutants exhibit low aneuploid rates as in the single mutants and survive to adulthood.

      (Rahmani et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      BubR1A1204K.PR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)