FlyBase Allele Report: Dmel\SmD3[HMS00361]

General Information

Symbol

Dmel\SmD3^HMS00361

Species

D. melanogaster

Name

FlyBase ID

FBal0248126

Feature type

allele

Associated gene

Dmel\SmD3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00361}

Also Known As

UAS-SmD3 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00361}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00361

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Phenotype Manifest In

egg chamber, with Scer\GAL4^{VP16.mat.αTub67C}

(Klusza et al., 2013)

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Detailed Description

Statement

Reference

Expressing SmD3^HMS00361 under the control of Scer\GAL4^Cg.PA leads to fragmented and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

Expression of SmD3^HMS00361 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in developmental arrest and degeneration of egg chambers by stage 5.

(Klusza et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

SmD3^HMS00361, Scer\GAL4^GMR.PU is an enhancer of abnormal size | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Hsieh et al., 2019)

SmD3^HMS00361, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU