FlyBase Allele Report: Dmel\kat-60L1[HMS00510]

General Information

Symbol

Dmel\kat-60L1^HMS00510

Species

D. melanogaster

Name

FlyBase ID

FBal0248261

Feature type

allele

Associated gene

Dmel\kat-60L1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00510}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00510}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00510

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.PG

(Herzmann et al., 2017)

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Sun et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Third instar larval adipocytes expressing kat-60L1^HMS00510 under the control of Scer\GAL4^Cg.PA abolishes the strong perinuclear microtubule distribution normally observed in controls, also causing nuclear enlargement and misposition.

(Sun et al., 2019)

Expression of kat-60L1^HMS00510 under the control of Scer\GAL4^ppk.PG results in modest dendrite pruning defects in class IV dendritic arborizing neurons at the pupal stage.

(Herzmann et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ppk.PG, kat-60L1^HMS00510 has abnormal neuroanatomy | pupal stage phenotype, enhanceable by par-1^HMS00405/Scer\GAL4^ppk.PG

(Herzmann et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ppk.PG, kat-60L1^HMS00510 has larval multidendritic class IV neuron | pupal stage phenotype, enhanceable by par-1^HMS00405/Scer\GAL4^ppk.PG

(Herzmann et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/kat-60L1^HMS00510 is a suppressor | partially of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Scer\GAL4^Cg.PA/kat-60L1^HMS00510 is a suppressor | partially of microtubule | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the pruning defects observed in class IV dendritic arborizing neurons of pupae expressing par-1^HMS00405 under the control of Scer\GAL4^ppk.PG is significantly enhanced by co-expression of kat-60L1^HMS00510, which on its own also induce mild pruning defects.

(Herzmann et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32506