FlyBase Gene Report: Dmel\kat-60L1

General Information

Symbol

Dmel\kat-60L1

Species

D. melanogaster

Name

katanin p60-like 1

Annotation Symbol

CG1193

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037375

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

microtubule-severing ATPase (5.6.1.1)

Gene Summary

katanin p60-like 1 (kat-60L1) encodes a microtubule-severing protein that regulates dendrite morphogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

83C3-83C4

Sequence location

3R:5,781,762..5,787,465 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5781762..5787465

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables microtubule severing ATPase activity

inferred from direct assay

(Sun et al., 2021)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000553508

(GO Reference Genome Project, 2011-)

enables microtubule binding

inferred from electronic annotation with InterPro:IPR028596

(InterPro Project Members, 2004-)

enables microtubule severing ATPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000553510

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR028596

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in microtubule cytoskeleton organization

inferred from mutant phenotype

(Sun et al., 2021)

involved_in microtubule severing

inferred from direct assay

(Sun et al., 2021)

involved_in neuron remodeling

inferred from mutant phenotype

(Lee et al., 2009)

involved_in positive regulation of dendrite morphogenesis

inferred from mutant phenotype

(Stewart et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in microtubule severing

inferred from electronic annotation with InterPro:IPR028596

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in ciliary basal body

inferred from direct assay

(Sun et al., 2021)

located_in microtubule

inferred from direct assay

(Sun et al., 2021, Stewart et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in spindle

inferred from biological aspect of ancestor with PANTHER:PTN000553510

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MICROTUBULE SEVERING ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

microtubule severing ATPase activity

n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers (5.6.1.1)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

katanin p60-like 1 (kat-60L1) encodes a microtubule-severing protein that regulates dendrite morphogenesis. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

MICROTUBULE SEVERING ATPASES -: Microtubule-severing ATPases generate internal breaks in microtubules. They are conserved in eukaryotes, and all three known microtubule-severing enzymes, katanin, spastin, and fidgetin, are members of the meiotic subfamily of AAA ATPases. If the newly generated microtubules are stable and regrow, then severing enzymes can act as microtubule amplifiers; if the newly severed microtubules are unstable, severing enzymes can act as depolymerases. Therefore, severing enzymes have the potential to be both positive and negative regulators of microtubule mass, and thus are implicated in regulating microtubule dynamics in a wide range of basic cellular processes ranging from ciliogenesis to cell division, neurogenesis, and phototropism. (Adapted from PMID:30373906.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\kat-60L1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q4QPP5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kat-60L1-RA

FBtr0078627

NM_141329

2301

605

kat-60L1-RB

FBtr0078628

NM_169105

2467

669

kat-60L1-RC

FBtr0300736

NM_001170050

2338

669

kat-60L1-RD

FBtr0300737

NM_001170051

2184

609

kat-60L1-RE

FBtr0300738

NM_001170052

2350

673

kat-60L1-RF

FBtr0300739

NM_001170053

2172

605

kat-60L1-RG

FBtr0300740

NM_001170054

2479

673

kat-60L1-RH

FBtr0300741

NM_001170055

2313

609

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

kat-60L1-PA

FBpp0078276

66.6

605

10.14

FBpp0078277

73.6

669

9.90

FBpp0289960

73.6

669

9.90

FBpp0289961

66.9

609

10.14

FBpp0289962

73.9

673

9.90

FBpp0289963

66.6

605

10.14

FBpp0289964

73.9

673

9.90

FBpp0289965

66.9

609

10.14

E1JJ62

NP_001163526

ACZ94825

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

605 aa isoforms: kat-60L1-PA, kat-60L1-PF

669 aa isoforms: kat-60L1-PB, kat-60L1-PC

609 aa isoforms: kat-60L1-PD, kat-60L1-PH

673 aa isoforms: kat-60L1-PE, kat-60L1-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kat-60L1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.76

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval brain

Comment: Assay specific to short kat-60L1 transcripts (kat-60L1-RA, RD, RF and RH).

(Stewart et al., 2012)

adult stage

testis

Comment: Transcripts encoding both kat-60L1 short (kat-60L1-RA, RD, RF and RH) and long transcripts (kat-60L1-RB, RC, RE, and RG) are expressed.

(Stewart et al., 2012)

Additional Descriptive Data

Both the short (kat-60L1-RA, kat-60L1-RD, kat-60L1-RF, and kat-60L1-RH) and long transcripts (kat-60L1-RB, kat-60L1-RC, kat-60L1-RE, and kat-60L1-RG) are expressed in adult testis. The short transcripts are also expressed in the third instar larval brains.

(Stewart et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in ciliary basal body

inferred from direct assay

(Sun et al., 2021)

located_in microtubule

inferred from direct assay

(Sun et al., 2021, Stewart et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kat-60L1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kat-60L1

View exonic expression by tissue for Dmel\kat-60L1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40715/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037375

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1193

Flygut - An atlas of the Drosophila adult midgut

FBgn0037375

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\kat-60L1

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kat-60L1

Transgenic constructs containing regulatory region of kat-60L1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6145

(Ryder, 2004.4.26)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kat-60L1^GD7435

viable, with Scer\GAL4^Mef2.PR

kat-60L1^GD7435

viable, with Scer\GAL4^pnr-MD237

kat-60L1^GD7435

viable (with kat-60L1^BE6)

kat-60L1^c01236

viable (with kat-60L1^c01236)

kat-60L1^BE6

Sterility

Allele

fertile

kat-60L1^c01236

Other Phenotypes

Allele

abnormal flight

abnormal flight (with kat-60L1^BE6)

kat-60L1^c01236

abnormal flight (with kat-60L1^c01236)

kat-60L1^BE6

abnormal heat stress response, with Scer\GAL4^ppk.1.9

kat-60L1^GD7435

abnormal heat stress response (with kat-60L1^BE6)

kat-60L1^c01236

abnormal heat stress response (with kat-60L1^c01236)

kat-60L1^BE6

abnormal locomotor behavior | adult stage | heat sensitive

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

kat-60L1^GD7435

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

kat-60L1^GD7435

abnormal neuroanatomy | P-stage | somatic clone

kat-60L1^F1

abnormal neuroanatomy | pupal stage

kat-60L1^c01236

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.PG

abnormal neuroanatomy | pupal stage (with Df(3R)Exel6145)

kat-60L1^c01236

abnormal neurophysiology | adult stage (with kat-60L1^BE6)

kat-60L1^c01236

abnormal neurophysiology | adult stage (with kat-60L1^c01236)

kat-60L1^BE6

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kat-60L1^GD7435

abnormal size (with kat-60L1^BE6)

kat-60L1^c01236

abnormal size (with kat-60L1^c01236)

kat-60L1^BE6

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

abnormal stress response, with Scer\GAL4^ppk.1.9

kat-60L1^GD7435

abnormal stress response (with kat-60L1^BE6)

kat-60L1^c01236

abnormal stress response (with kat-60L1^c01236)

kat-60L1^BE6

short lived

short lived (with kat-60L1^BE6)

kat-60L1^c01236

short lived (with kat-60L1^c01236)

kat-60L1^BE6

visible, with Scer\GAL4^pnr-MD237

kat-60L1^GD7435

Phenotype manifest in

Allele

centriole (with kat-60L1^BE6)

kat-60L1^c01236

centriole (with kat-60L1^c01236)

kat-60L1^BE6

chaeta | increased number, with Scer\GAL4^pnr-MD237

kat-60L1^GD7435

cilium (with kat-60L1^BE6)

kat-60L1^c01236

cilium (with kat-60L1^c01236)

kat-60L1^BE6

dendrite, with Scer\GAL4^ppk.1.9

kat-60L1^GD7435

dendrite (with kat-60L1^BE6)

kat-60L1^c01236

dendrite (with kat-60L1^c01236)

kat-60L1^BE6

dendrite & dorsal multidendritic neuron ddaC | pupal stage

kat-60L1^c01236

dendrite & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^ppk.PG

kat-60L1^GD7435

dendrite & dorsal multidendritic neuron ddaC | pupal stage (with Df(3R)Exel6145)

kat-60L1^c01236

dendrite | P-stage | somatic clone

kat-60L1^F1

dendrite | pupal stage, with Scer\GAL4^ppk.PG

kat-60L1^HMS00510

embryonic/larval sensory neuron | P-stage | somatic clone

kat-60L1^F1

fat cell | third instar larval stage

kat-60L1^BE6

fat cell | third instar larval stage, with Scer\GAL4^Cg.PA

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

kat-60L1^GD7435

larval multidendritic class IV neuron (with kat-60L1^BE6)

kat-60L1^c01236

larval multidendritic class IV neuron (with kat-60L1^c01236)

kat-60L1^BE6

larval multidendritic class IV neuron | pupal stage, with Scer\GAL4^ppk.PG

kat-60L1^HMS00510

mechanosensory chaeta (with kat-60L1^BE6)

kat-60L1^c01236

mechanosensory chaeta (with kat-60L1^c01236)

kat-60L1^BE6

mechanosensory neuron of leg campaniform sensillum, with Scer\GAL4^DCX-EMAP.PS

kat-60L1^HMS00510

mechanosensory neuron of leg campaniform sensillum (with kat-60L1^BE6)

kat-60L1^c01236

mechanosensory neuron of leg campaniform sensillum (with kat-60L1^c01236)

kat-60L1^BE6

microtubule, with Scer\GAL4^DCX-EMAP.PS

kat-60L1^HMS00510

microtubule (with kat-60L1^BE6)

kat-60L1^c01236

microtubule (with kat-60L1^c01236)

kat-60L1^BE6

microtubule & dorsal multidendritic neuron ddaC | pupal stage

kat-60L1^c01236

microtubule | third instar larval stage

kat-60L1^BE6

microtubule | third instar larval stage, with Scer\GAL4^Cg.PA

nucleus | third instar larval stage, with Scer\GAL4^Cg.PA

sensory neuron of haltere campaniform sensillum (with kat-60L1^BE6)

kat-60L1^c01236

sensory neuron of haltere campaniform sensillum (with kat-60L1^c01236)

kat-60L1^BE6

sensory neuron of haltere campaniform sensillum | adult stage (with kat-60L1^BE6)

kat-60L1^c01236

sensory neuron of haltere campaniform sensillum | adult stage (with kat-60L1^c01236)

kat-60L1^BE6

trichogen cell, with Scer\GAL4^pnr-MD237

kat-60L1^GD7435

vesicle | increased number (with kat-60L1^BE6)

kat-60L1^c01236

vesicle | increased number (with kat-60L1^c01236)

kat-60L1^BE6

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (36)

Hsap\KATNA1

9 of 14

Yes

Hsap\KATNAL1

9 of 14

Yes

Hsap\KATNAL2

3 of 14

Hsap\ATAD1

2 of 14

Hsap\ATAD2B

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (26)

Rnor\Katna1

9 of 14

Yes

Rnor\Katnal1

9 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Katna1

9 of 14

Yes

Mmus\Katnal1

9 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Yes

Mmus\Atad2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (27)

Xtro\katna1

6 of 13

Yes

Xtro\katnal1

6 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (22)

Drer\katna1

9 of 14

Yes

Drer\katnal1

9 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (24)

Cele\mei-1

9 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP001783

5 of 12

Yes

Agam\AgaP_AGAP003241

4 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (83)

Atha\ERH3

9 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (22)

Scer\SAP1

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (13)

Spom\SPAC328.04

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Spom\SPCC24B10.10c

1 of 12

Spom\vps4

1 of 12

Spom\yta12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\glpK

1 of 11

Yes

Ecol\wecF

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:kat-60L1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (33)

11 of 13

5 of 13

3 of 13

3 of 13

3 of 13

2 of 13

nmd

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

bor

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Gk1

1 of 13

Gk2

1 of 13

Lon

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KATNA1; katanin catalytic subunit A1

9 of 14

606696

KATNAL1; katanin catalytic subunit A1 like 1

9 of 14

614764

KATNAL2; katanin catalytic subunit A1 like 2

3 of 14

614697

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kat-60L1

enhanceable

par-1

(Herzmann et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

shot

suppressible

kat-60L1

(Sun et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65920

DroID - A comprehensive database of gene and protein interactions.

FBgn0037375

MIST (protein-protein) - An integrated Molecular Interaction Database

40715

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83C3-83C4

Sequence location

3R:5,781,762..5,787,465 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83C3-83C4

Limits computationally determined from genome sequence between P{lacW}cas^j1C2 and P{PZ}lab⁰¹²⁴¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

10430

w¹¹¹⁸; PBac{PB}kat-60L1^c01236

32506

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00510}attP2

36866

y¹ sc^* v¹ sev²¹; P{TRiP.GL01001}attP40

NIG-Fly

HMJ22511

y¹ v¹; P{TRiP.HMJ22511}attP40/CyO

HMS00510

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00510}attP2

VDRC

v108168

P{KK103714}VIE-260B

v31598

w¹¹¹⁸; P{GD7435}v31598

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (50)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH23455

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037375

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

AT01673
AT01827
AT02096
AT03380
AT04378
AT06257
AT10109
AT10325
AT11286
AT12060
AT12167
AT12192
AT12692
AT14696
AT15841
AT16571
AT16589
AT16758
AT21240
AT22561
AT24743
AT25282
AT25395
AT29038
AT29327
AT30529
AT30721
AT30962
GH15774
GH24872
HL01711
LP04230
LP20811

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037375

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

kat-60L1 is not required for the axonal projection of larval class IV da neurons, but it is required to establish their highly branched dendritic arbour and mediate their nocifensive functions.

(Stewart et al., 2012)

kat-60L1 is not required for initial dendritic branch formation in the larva, but rather for arborization after 72 hours AEL during third-instar larval development.

(Stewart et al., 2012)

kat-60L1 has a role in up-regulating the number, but not the rate, of growing microtubules in the dendrites of class IV neurons, thereby promoting branch stabilization of the dendritic arbor during third-instar larval development.

(Stewart et al., 2012)

kat-60L1 is required for dendritic severing during dendrite pruning of ddaC neurons in the pupa.

(Lee et al., 2009)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: kat-60L1 CG1193

(Lee et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1193

(National Institute of Genetics Fly Stocks, 2023-, Fukuoh et al., 2014, Katzenberger et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lee et al., 2009, Bakal et al., 2007, Zhang et al., 2007)

DmCG1193

(Frohlich, 2001)

Kat-60L1

(Song et al., 2023, Bu et al., 2022, Bu et al., 2021, Furusawa and Emoto, 2021, Sun et al., 2021, Tang et al., 2020)

kat-60L1

(Liu et al., 2023, Bu et al., 2022, Kitatani et al., 2020, Zheng et al., 2020, Herzmann et al., 2017, Baxter et al., 2014, Stewart et al., 2012, Lee et al., 2009)

kat60L1

(Wolterhoff et al., 2020)

Name Synonyms

CG1193

Katanin

(Bu et al., 2022)

Katanin-p60L1

(Tao and Rolls, 2011)

katanin p60-like 1

(Stewart et al., 2012, Lee et al., 2009)

katanin-p60L1

(Tao et al., 2016)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40715

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q4QPP5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q4QPP5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40715/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037375

FlyMine - An integrated database for Drosophila genomics

FBgn0037375

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1193

MARRVEL_MODEL - MARRVEL (model organism gene)

40715

Linkouts

BioGRID - A database of protein and genetic interactions.

65920

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037375

DroID - A comprehensive database of gene and protein interactions.

FBgn0037375

DRSC - Results frm RNAi screens

FBgn0037375

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037375

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1193

Flygut - An atlas of the Drosophila adult midgut

FBgn0037375

MIST (protein-protein) - An integrated Molecular Interaction Database

40715

References (59)

The following external sites may use different assemblies or annotations than FlyBase.

4.76

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