FlyBase Gene Report: Dmel\Gk1

General Information

Symbol

Dmel\Gk1

Species

D. melanogaster

Name

Glycerol kinase 1

Annotation Symbol

CG18374

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025592

Gene Model Status

Current

Stock Availability

12 publicly available

Enzyme Name (EC)

glycerol kinase (2.7.1.30)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Gyk, glycerol kinase, dGyk

Key Links

Genomic Location

Cytogenetic map

61B2-61B2

Sequence location

3L:202,098..205,844 [-]

Recombination map

3-1

RefSeq locus

NT_037436 REGION:202098..205844

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables glycerol kinase activity

inferred from mutant phenotype

(Wightman et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables glycerol kinase activity

inferred from sequence or structural similarity with UniProtKB:P32189

(Martinez Agosto and McCabe, 2006)

inferred from electronic annotation with InterPro:IPR005999

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000023392

(GO Reference Genome Project, 2011-)

enables kinase activity

inferred from electronic annotation with InterPro:IPR000577, InterPro:IPR018484, InterPro:IPR018485

(InterPro Project Members, 2004-)

enables phosphotransferase activity, alcohol group as acceptor

inferred from electronic annotation with InterPro:IPR018483

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in glycerol-3-phosphate biosynthetic process

inferred from mutant phenotype

(Wightman et al., 2012)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR000577, InterPro:IPR018483, InterPro:IPR018484, InterPro:IPR018485

(InterPro Project Members, 2004-)

involved_in glycerol metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000023394

(GO Reference Genome Project, 2011-)

involved_in glycerol-3-phosphate biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000023394

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P32189

(Martinez Agosto and McCabe, 2006)

involved_in glycerol-3-phosphate metabolic process

inferred from electronic annotation with InterPro:IPR005999

(InterPro Project Members, 2004-)

involved_in triglyceride metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000023394

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from sequence or structural similarity with UniProtKB:P32189-4

(Gene Ontology Curators, 2002-)

is_active_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:P32189-3

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000023394

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:P32189-3

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

GLYCEROL KINASE

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

glycerol kinase activity

glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+) (2.7.1.30)

RHEA 21644:

Summaries

Gene Group (FlyBase)

GLYCEROL KINASE -: Glycerol kinases catalyze the formation of glycerol 3-phosphate by the transfer of phosphate from ATP to glycerol. (Adapted from FBrf0193831).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gk1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0U0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gk1-RA

FBtr0072529

NM_079916

1933

538

Gk1-RB

FBtr0072530

NM_167803

1713

474

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gk1-PA

FBpp0072428

58.8

538

5.01

FBpp0072429

51.8

474

6.37

Q8IRJ9

NP_728486

AAN11423

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gk1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gyk_1
Gyk_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.87

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gk1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gk1

View exonic expression by tissue for Dmel\Gk1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025592

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43913/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025592

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025592

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025592

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18374

Flygut - An atlas of the Drosophila adult midgut

FBgn0025592

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gk1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gk1

Transgenic constructs containing regulatory region of Gk1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6084

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^c564

Gk1^RNAi.UAS

partially lethal, with Scer\GAL4^how-24B

Gk1^RNAi.UAS

partially lethal, with Scer\GAL4^αTub84B.PL

Gk1^RNAi.UAS

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gk1^GD9566

viable, with Scer\GAL4^tin.CΔ4

Gk1^GD9566

Sterility

Allele

fertile

Gk1^e00237

Other Phenotypes

Allele

chemical sensitive, with Scer\GAL4^c564

Gk1^RNAi.UAS

chemical sensitive | recessive

Gk1^e00237

melanotic mass phenotype | third instar larval stage, with Scer\GAL4^c564

Gk1^RNAi.UAS

short lived | nutrition conditional

Gk1^RNAi.UAS

visible | pharate adult stage, with Scer\GAL4^c564

Gk1^RNAi.UAS

Phenotype manifest in

Allele

melanotic mass | third instar larval stage, with Scer\GAL4^c564

Gk1^RNAi.UAS

wing | pharate adult stage, with Scer\GAL4^c564

Gk1^RNAi.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\GK2

13 of 14

Yes

Hsap\GK

13 of 14

Yes

Hsap\GK3P

11 of 14

Yes

Hsap\GK5

3 of 14

Hsap\FGGY

2 of 14

Hsap\SHPK

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Gk

14 of 14

Yes

Rnor\Gk2

13 of 14

Yes

Rnor\Gykl1

13 of 14

Yes

Rnor\Gk5

3 of 14

Rnor\Fggy

2 of 14

Rnor\Shpk

2 of 14

Yes

Rnor\Atad2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Gk

14 of 14

Yes

Mmus\Gykl1

13 of 14

Yes

Mmus\Gk2

12 of 14

Yes

Mmus\Gk5

3 of 14

Mmus\Fggy

2 of 14

Mmus\Shpk

2 of 14

Yes

Mmus\Atad2b

1 of 14

Yes

Mmus\Atad2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\gk

10 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slc52a1

1 of 13

Danio rerio (Zebrafish) (11)

Drer\zgc:172295

13 of 14

Yes

Drer\gk5

3 of 14

Drer\shpk

2 of 14

Yes

Drer\atad2b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\R11F4.1

13 of 14

Yes

Cele\C55B6.1

2 of 14

Cele\shpk-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP006778

12 of 12

Yes

6 of 12

4 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\NHO1

13 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\GUT1

12 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\rpt1

1 of 12

Yes

Spom\rpt2

1 of 12

Yes

Spom\rpt6

1 of 12

Yes

Spom\SPAC31G5.19

1 of 12

Yes

Spom\SPBP22H7.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (9)

Ecol\glpK

11 of 11

Yes

Ecol\fucK

2 of 11

Ecol\lsrK

2 of 11

Yes

Ecol\rhaB

2 of 11

Ecol\ygcE

2 of 11

Yes

Ecol\araB

1 of 11

Ecol\lyxK

1 of 11

Ecol\wecF

1 of 11

Yes

Ecol\xylB

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gk1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

Gk2

11 of 13

8 of 13

5 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

glycerol kinase deficiency

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Gk1^RNAi.UAS

model of glycerol kinase deficiency

CEA

(Wightman et al., 2012)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GK; glycerol kinase

model of glycerol kinase deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GK2; glycerol kinase 2

13 of 14

600148

GK; glycerol kinase

13 of 14

GLYCEROL KINASE; GK

GLYCEROL KINASE DEFICIENCY; GKD

glycerol kinase deficiency

GK3; glycerol kinase 3

11 of 14

600149

GK5; glycerol kinase 5

3 of 14

620801

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Gk1 - boca

experimental knowledge based

(Guruharsha et al., 2011)

Gk1 - mamo

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gk1

enhanceable

(Wightman et al., 2012)

Gk1

suppressible

(Wightman et al., 2012)

Gk1

enhanceable

(Wightman et al., 2012)

Gk1

suppressible

Gk2

(Wightman et al., 2012)

Gk1

enhanceable

Gpdh1

(Wightman et al., 2013)

Gk1

enhanceable

(Wightman et al., 2012)

Gk1

enhanceable

(Wightman et al., 2012)

Gk1

enhanceable

(Wightman et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025592

MIST (genetic) - An integrated Molecular Interaction Database

43913

MIST (protein-protein) - An integrated Molecular Interaction Database

43913

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

glycerol degradation I

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Triglyceride biosynthesis

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Triglyceride biosynthesis

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-1

Cytogenetic map

61B2-61B2

Sequence location

3L:202,098..205,844 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61B2-61B2

Limits computationally determined from genome sequence between P{PZ}trh¹⁰⁵¹² and P{EP}EP3104^EP3104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-1

(FlyBase, 2016)

3-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

51849

y¹ v¹; P{TRiP.HMC03423}attP40

35188

y¹ sc^* v¹ sev²¹; P{TRiP.GL00060}attP2

79403

y¹ sc^* v¹ sev²¹; P{TKO.GS00873}attP40

80720

y¹ sc^* v¹ sev²¹; P{TOE.GS01229}attP40

22516

y¹ w^67c23; P{EPgy2}Gk1^EY21867/TM3, Sb¹ Ser¹

11102

11608

18374R-1

v110806

v52478

w¹¹¹⁸ P{GD9566}v52478

v318706

PBac{fTRG00983.sfGFP-TVPTBF}VK00002

v342922

P{hsFLP}1, y1 w1118; P{HD_CFD02247}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH12641

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025592

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025592

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Gyk CG18374

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gk1 Gyk

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'Gyk' to 'Gk1', as 'Gk' is the standard abbreviation for 'glycerol kinase', it was the first gene encoding a glycerol kinase in D.melanogaster to be characterized, and it is the closest homolog to human GK genes (also see FBrf0193831).

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG18374

(Meadows, 2014.12.12, Wightman et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Martinez Agosto and McCabe, 2006)

Gk1

(Kim et al., 2024, Gene Disruption Project members, 2018-, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-)

Gyk

(Sarov et al., 2016, Bartok et al., 2015, Yuan et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Wasbrough et al., 2010, Curtis et al., 2007, Martinez Agosto and McCabe, 2006)

dGyk

(Wightman et al., 2013, Wightman et al., 2012)

Name Synonyms

Glycerol kinase

(Anholt and Williams, 2010, Pekarsky et al., 1998)

Glycerol kinase 1

glycerol kinase

(Bartok et al., 2015, Curtis et al., 2007, Teleman et al., 2005)

Secondary FlyBase IDs

FBgn0035108

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43913

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0U0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0U0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025592

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43913/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025592

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025592

FlyMine - An integrated database for Drosophila genomics

FBgn0025592

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18374

MARRVEL_MODEL - MARRVEL (model organism gene)

43913

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025592

DroID - A comprehensive database of gene and protein interactions.

FBgn0025592

DRSC - Results frm RNAi screens

FBgn0025592

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gyk_1
Gyk_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025592

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025592

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

glycerol degradation I

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18374

Flygut - An atlas of the Drosophila adult midgut

FBgn0025592

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0025592

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

43913

MIST (protein-protein) - An integrated Molecular Interaction Database

43913

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Triglyceride biosynthesis

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Triglyceride biosynthesis

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

0.87

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