FlyBase Gene Report: Dmel\Pex1

General Information

Symbol

Dmel\Pex1

Species

D. melanogaster

Name

Peroxin 1

Annotation Symbol

CG6760

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013563

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Peroxin 1 (Pex1) encodes a member of the family of AAA-ATPases required for peroxisome assembly. Pex1 loss results in disorganization of neurons and glia and embryonic lethality. Larval escapers exhibit developmental delay, poor feeding and uncoordinated locomotion. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)70Da, l(3)s4868, l(3)S084807, l(3)02402, lethal (3) 70Da

Key Links

Genomic Location

Cytogenetic map

70D1-70D2

Sequence location

3L:14,071,892..14,076,123 [+]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14071892..14076123

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960, InterPro:IPR015342

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN004603074

(GO Reference Genome Project, 2011-)

enables protein transporter activity

inferred from sequence or structural similarity with UniProtKB:Q13608

(Gene Ontology Curators, 2002-)

enables ubiquitin-modified protein reader activity

inferred from sequence or structural similarity with UniProtKB:O43933

(Gene Ontology Curators, 2002-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in central nervous system development

inferred from mutant phenotype

(Mast et al., 2011)

involved_in glial cell development

inferred from mutant phenotype

(Mast et al., 2011)

involved_in peripheral nervous system development

inferred from mutant phenotype

(Mast et al., 2011)

involved_in peroxisome organization

inferred from mutant phenotype

(Mast et al., 2011)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in peroxisome organization

inferred from sequence or structural similarity with UniProtKB:O43933

(Faust et al., 2012)

inferred from electronic annotation with InterPro:IPR015342

(InterPro Project Members, 2004-)

involved_in protein import into peroxisome matrix, receptor recycling

inferred from sequence or structural similarity with UniProtKB:O43933

(Gene Ontology Curators, 2002-)

involved_in protein import into peroxisome matrix

inferred from biological aspect of ancestor with PANTHER:PTN000554669

(GO Reference Genome Project, 2011-)

involved_in protein unfolding

inferred from sequence or structural similarity with UniProtKB:O43933

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000554669

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in peroxisome

inferred from direct assay

(Baron et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000554669

(GO Reference Genome Project, 2011-)

is_active_in peroxisomal membrane

inferred from biological aspect of ancestor with PANTHER:PTN000554669

(GO Reference Genome Project, 2011-)

located_in peroxisome

inferred from sequence or structural similarity with UniProtKB:O43933

(Faust et al., 2012)

inferred from electronic annotation with InterPro:IPR015342

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

PEROXINS

UNCLASSIFIED ATPASES

PEROXISOMAL MEMBRANE EXTRACTION COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

Gene Group (FlyBase)

PEROXINS -: Peroxisomes are eukaryotic organelles critical for the metabolism of fatty acids, particularly very-long-chain fatty acids, and other metabolites. The peroxin genes encode proteins required for peroxisome biogenesis. (Adapted from FBrf0209624).
UNCLASSIFIED ATPASES -: This group comprises ATPases that do not classify under other groups in FlyBase.
PEROXISOMAL MEMBRANE EXTRACTION COMPLEX -: Peroxisomal membrane extraction complex is an ATPase chaperone complex that interacts with monoubiquitinated Pex5 cargo receptor in the peroxisomal ubiquitin ligase retrotranslocon complex. It promotes the ATP-dependent unfolding of Pex5 and extracts it into the cytosol. This drives peroxisomal matrix import cycle, allowing the cargo receptor to be available of further rounds import. (Adapted from PMID:36442669 and PMID:36117327.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pex1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VUC7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pex1-RA

FBtr0075777

NM_143759

3275

1006

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pex1-PA

FBpp0075519

113.9

1006

7.60

Q9VUC7

NP_652016

AAF49760

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1006 (aa); 114 (kD predicted)

(Burmester et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pex1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pex1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.90

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4

yolk

(Pridie and Simmonds, 2021)

embryonic stage 7 -- 8

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Pex1 FISH signal is observed in the yolk in early embryos. Levels are close to background after cellularization.

(Pridie and Simmonds, 2021)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in peroxisome

inferred from direct assay

(Baron et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pex1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pex1

View exonic expression by tissue for Dmel\Pex1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013563

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45460/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013563

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013563

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013563

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6760

Flygut - An atlas of the Drosophila adult midgut

FBgn0013563

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pex1

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pex1

Transgenic constructs containing regulatory region of Pex1

Aberrations (Deficiencies and Duplications) ( 18 )

Inferred from experimentation ( 18 )

Gene duplicated in

Dp(3;3)D^4rv36

(Carpenter, 1994)

Gene partially disrupted in

Df(3L)D-4rv34

(Carpenter, 1994)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Pex1^s4868

lethal (with Df(3L)fz-GF3b)

Pex1^S084807

lethal (with Df(3L)fz-GS1a)

lethal (with Pex1¹)

Pex1^s4868

lethal (with Pex1^s4868)

Pex1¹

lethal | recessive

lethal - all die before end of larval stage

Pex1¹

lethal - all die before end of larval stage | recessive

Pex1^s4868

partially lethal, with Scer\GAL4^Act5C.PU

Pex1^UAS.cMa

partially lethal - majority die

Pex1⁰²⁴⁰²

partially lethal - majority die | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pex1^GD12029

viable, with Scer\GAL4^Mef2.PR

Pex1^GD12029

viable, with Scer\GAL4^pnr-MD237

Pex1^GD12029

viable, with Scer\GAL4^tin.CΔ4

Pex1^GD12029

Other Phenotypes

Allele

abnormal body size | larval stage | recessive

Pex1^s4868

abnormal cytokinesis

Pex1^s4868

abnormal developmental rate | larval stage | recessive

Pex1^s4868

abnormal feeding behavior | larval stage | recessive

Pex1^s4868

abnormal locomotor behavior | larval stage | recessive

Pex1^s4868

abnormal meiotic cell cycle

Pex1^s4868

abnormal neuroanatomy | embryonic stage 15

Pex1^s4868

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

Pex1^HMC03252

decreased fecundity, with Scer\GAL4^Act5C.PU

Pex1^UAS.cMa

decreased fecundity, with Scer\GAL4^elav-C155

Pex1^UAS.cMa

increased cell death | larval stage

Pex1^unspecified

some die during larval stage

Pex1¹

some die during larval stage | recessive

Pex1^s4868

Phenotype manifest in

Allele

anterior spiracle primordium | embryonic stage 15

Pex1^s4868

central nervous system | embryonic stage 15

Pex1^s4868

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

Pex1^HMC03252

embryonic/larval salivary gland | embryonic stage

Pex1^unspecified

embryonic brain | embryonic stage 15

Pex1^s4868

eye-antennal disc primordium | embryonic stage 15

Pex1^s4868

larval glial cell | embryonic stage 15

Pex1^s4868

larval ventral nerve cord | embryonic stage 15

Pex1^s4868

Malpighian tubule primordium | embryonic stage 15

Pex1^s4868

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

Pex1^HMC03252

peripheral nervous system | embryonic stage 15

Pex1^s4868

posterior spiracle primordium | embryonic stage 15

Pex1^s4868

spermatid

Pex1^s4868

testis

Pex1^s4868

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (22)

Hsap\PEX1

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Pex1

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Pex1

11 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (17)

Xtro\pex1

9 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Xtro\atad2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\nvl

1 of 13

Xtro\pex6

1 of 13

Xtro\prxl2a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (18)

Drer\pex1

11 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-195m11.8

1 of 14

Drer\spast

1 of 14

Drer\trip13

1 of 14

Drer\zgc:153738

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (18)

Cele\prx-1

9 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP010924

12 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\PEX1

11 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (15)

Scer\PEX1

11 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (10)

Spom\pex1

10 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pex1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

5 of 13

5 of 13

5 of 13

5 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

nmd

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

peroxisome biogenesis disorder 1A

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Pex1¹

model of Zellweger syndrome

CEA

(Mast et al., 2011)

model of peroxisome biogenesis disorder 1B

CEC

(Mast et al., 2011)

Pex1^s4868

model of Zellweger syndrome

CEA

(Mast et al., 2011)

model of peroxisome biogenesis disorder 1B

CEC

(Mast et al., 2011)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

PEX1; peroxisomal biogenesis factor 1

model of peroxisome biogenesis disorder 1B

IEA

(FlyBase, 2019-)

model of peroxisome biogenesis disorder 1A

IEA

(FlyBase, 2019-)

model of Heimler syndrome 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PEX1; peroxisomal biogenesis factor 1

12 of 14

PEROXISOME BIOGENESIS FACTOR 1; PEX1

NVL; nuclear VCP like

3 of 14

602426

AFG2A; AAA ATPase AFG2A

3 of 14

613940

NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS, SEIZURES, AND BRAIN ABNORMALITIES; NEDHSB

AFG2B; AAA ATPase AFG2B

3 of 14

619578

VCP; valosin containing protein

3 of 14

VALOSIN-CONTAINING PROTEIN; VCP

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69691

DroID - A comprehensive database of gene and protein interactions.

FBgn0013563

MIST (protein-protein) - An integrated Molecular Interaction Database

45460

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Peroxisome

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70D1-70D2

Sequence location

3L:14,071,892..14,076,123 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70D1-70D2

Limits computationally determined from genome sequence between P{EP}EP3561^EP3561 and P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70D1-70D1

(determined by in situ hybridisation)

(Burmester et al., 2000)

70D1-70D1

(Mink, 1999.2.5, Mink, 1999.2.5)

70C1-70C2

(determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation)

(Spradling et al., 1999)

70D1-70D2

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

70C1-70C2

70D1--2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-35.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28979

y¹ v¹; P{TRiP.HM05190}attP2

51497

y¹ v¹; P{TRiP.HMC03252}attP2

92538

y¹ v¹; P{U6.2-Pex1.dgRNA}attP40/CyO

91938

y¹ sc^* v¹ sev²¹; P{TKO.GS00024}attP40/CyO

93378

y¹ w^*; TI{CRIMIC.TG4.0}Pex1^{CR70207-TG4.0}/TM3, Sb¹ Ser¹

4860

mwh¹ Pex1¹ red¹ e⁴/TM3, P{Thb8-lacZ}WD1, Sb¹ Ser¹

10177

w¹¹¹⁸; P{lacW}Pex1^s4868/TM3, P{ftz-lacC}SC1, ry^RK Sb¹ Ser¹

NIG-Fly

HMC03252

y¹ v¹; P{TRiP.HMC03252}attP2

HMJ22376

y¹ v¹; P{TRiP.HMJ22376}attP40/CyO

VDRC

v27743

P{GD12029}v27743

v27741

w¹¹¹⁸; P{GD12029}v27741

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD43687

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0013563

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP21483

Other clones

RP004226670

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013563

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mast et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2R+ : A stable S2 cell line deleted for the Pex1 gene was created.
(Nath et al., 2022)

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: l(3)70Da CG6760

(Bayraktaroglu, 2000.4.12)

Source for merge of: l(3)70Da anon-WO0172774.100 anon-WO0172774.101 anon-WO0172774.102 anon-WO0172774.96 anon-WO0172774.99

(FlyBase, 1996-)

Additional comments

Source for merge of l(3)70Da anon-WO0172774.100 anon-WO0172774.101 anon-WO0172774.102 anon-WO0172774.96 anon-WO0172774.99 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: pex1 l(3)70Da

(Chen et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

0848/07

(Deak et al., 1997)

CG6760

(National Institute of Genetics Fly Stocks, 2023-, Trivedi et al., 2020, Baron et al., 2016, Çiçek et al., 2016, Balakrishnan et al., 2015, Sing et al., 2014, Faust et al., 2012, Faust et al., 2012, Mast et al., 2011, Ni et al., 2010.12.1)

DmCAB51031.1

(Frohlich, 2001)

DmelPex1

(Mast et al., 2011)

PEX1

(Anderson-Baron and Simmonds, 2018, Baron et al., 2016, Faust et al., 2012, Mast et al., 2011)

Pex1

(Li et al., 2023, Ueda et al., 2022, Pridie and Simmonds, 2021, Huang et al., 2020, Pridie et al., 2020, Hughes and Simmonds, 2019, Zhou et al., 2019, Anderson-Baron and Simmonds, 2018, Gene Disruption Project members, 2018-, Deb and Nagotu, 2017, Transgenic RNAi Project members, 2017-, Holderbaum et al., 2012.4.9, Mast et al., 2011)

anon-WO0172774.100

anon-WO0172774.101

anon-WO0172774.102

anon-WO0172774.96

anon-WO0172774.98

anon-WO0172774.99

l(3)02402

(Mink, 1999.2.5)

l(3)084807

(Mink, 1999.2.5)

l(3)70Da

(Japanese National Institute of Genetics, 2012.5.21, Mast et al., 2011, Schrider et al., 2011, Wasbrough et al., 2010)

l(3)S084807

(Maroy, 1999.4.20)

l(3)s4868

(Maroy, 1999.4.20, Spradling et al., 1999)

pex1

(Izutsu et al., 2012, Chen et al., 2010)

Name Synonyms

Peroxin 1

(Anderson-Baron and Simmonds, 2018)

lethal (3) 70Da

(Faust et al., 2012)

peroxin 1

Secondary FlyBase IDs

FBgn0024587
FBgn0026223
FBgn0028085
FBgn0036409
FBgn0046338
FBgn0046339
FBgn0046340
FBgn0046489
FBgn0046490
FBgn0046491

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45460

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VUC7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VUC7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013563

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45460/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013563

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013563

FlyMine - An integrated database for Drosophila genomics

FBgn0013563

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6760

MARRVEL_MODEL - MARRVEL (model organism gene)

45460

Linkouts

BioGRID - A database of protein and genetic interactions.

69691

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0013563

DroID - A comprehensive database of gene and protein interactions.

FBgn0013563

DRSC - Results frm RNAi screens

FBgn0013563

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pex1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013563

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013563

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6760

Flygut - An atlas of the Drosophila adult midgut

FBgn0013563

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014648

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Peroxisome

MIST (protein-protein) - An integrated Molecular Interaction Database

45460

References (73)

The following external sites may use different assemblies or annotations than FlyBase.

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