FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ShrmB.UAS
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General Information
Symbol
Dmel\ShrmB.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0248403
Feature type
allele
Associated gene
Dmel\Shrm
Associated Insertion(s)
Carried in Construct
P{UAS-Shrm.B}
Key Links
Transgenic product class
wild_type
(Bolinger et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bolinger et al., 2010)
Mutagen
in vitro construct
(Bolinger et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Shrm.B}
Cytology
Description

UASt regulatory sequences drive expression of Shroom isoform-B coding sequences.

(Bolinger et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Shrm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of ShrmB.UAS under the control of Scer\GAL4A9 induces a small wrinkled wing.

      (Hildebrand et al., 2021)

      Expression of ShroomB.Scer\UAS under the control of Scer\GAL4arm.PS results in embryonic lethality due to multiple defects in morphogenesis. This appears to results from excessive apical constriction and subsequent disruption of the adherens junction in the embryonic ectoderm.

      Overexpression of ShroomB.Scer\UAS in the dorsal ectoderm under the control of Scer\GAL4pnr-MD237 causes defects in dorsal closure but most mutant embryos complete the process. However, many of these embryos show defects at the cellular level such that the leading edge cells are not elongated along the dorsal-ventral axis and the segments are not often matched correctly at the midline. As a result, approximately 45% of these embryos exhibit variable defects at the dorsal midline, ranging from completely open to small holes or puckering. ShroomB.Scer\UAS expression causes leading edge cells to lose their elongated shape and appear apically constricted, exhibiting an approximate 50% decrease in apical area.

      (Bolinger et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of rokSBD.Scer\UAS.T:Hsap\MYC with ShroomB.Scer\UAS, both under the control of Scer\GAL4pnr-MD237 blocks the epithelial cell apical constriction seen in ShroomA.Scer\UAS single mutants.

      (Bolinger et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ShrmB.UAS
      ShroomB.Scer\UAS
      ShroomB.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)