FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pgam5UAS.cIa
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General Information
Symbol
Dmel\Pgam5UAS.cIa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Imai
FlyBase ID
FBal0248711
Feature type
allele
Associated gene
Dmel\Pgam5
Associated Insertion(s)
Carried in Construct
P{UAS-Pgam5.I}
Also Known As
UAS-dPGAM5
Key Links
Transgenic product class
cDNA
(Imai et al., 2010)
wild_type
(Imai et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Imai et al., 2010)
wild_type
(Imai et al., 2010)
Mutagen
in vitro construct
(Imai et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Pgam5.I}
Cytology
Description

UASt regulatory sequences drive expression of a Pgam5 cDNA.

(Imai et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pgam5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Pgam5Scer\UAS.cIa under the control of Scer\GAL4da.G32 have a shorter lifespan compared to control flies.

      Mitochondria in the indirect flight muscles are shorter in the long-axis direction than normal in 2 day old adults expressing Pgam5Scer\UAS.cIa under the control of Scer\GAL4da.G32.

      (Imai et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Pgam5UAS.cIa/Scer\GAL4da.PU is an enhancer of wing phenotype of Pink1B9

      (Imai et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The progressive abnormal wing posture phenotype, the progressive loss of climbing ability and the reduction in lifespan seen in Pink1B9 flies are enhanced by expression of Pgam5Scer\UAS.cIa under the control of Scer\GAL4da.G32.

      Expression of Pgam5Scer\UAS.cIa under the control of Scer\GAL4da.G32 enhances both the progressive loss in climbing ability and reduction in lifespan seen in parkP21 flies.

      (Imai et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Pgam5UAS.cIa/Scer\GAL4c739 rescues Pgam51

      (Ishida et al., 2012)
      Comments

      Expression of Pgam5Scer\UAS.cIa in mushroom bodies under the control of Scer\GAL4c739 rescues the heat shock sensitivity seen in Pgam51 mutant flies.

      (Ishida et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pgam5Scer\UAS.cIa
      Pgam5UAS.cIa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Imai
      Secondary FlyBase IDs
        References (2)