FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\parkP21
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General Information
Symbol
Dmel\parkP21
Species
D. melanogaster
Name
FlyBase ID
FBal0158833
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
P{EP}P21
P{EP}P30
Carried in Construct
Also Known As
parkinP21
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Pesah et al., 2004)
Progenitor genotype
parkP30
(Pesah et al., 2004)
Associated Insertion(s)
P{EP}P21
P{EP}P30
Cytology
Description

An insertion of P{EP} at 29bp 5' to the park transcriptional start site, generated by mobilising P{EP}parkP30, which is still present.

(Pesah et al., 2004)
Allele components
Component
Use(s)
Inserted element
P{EP}
P{EP}
Regulatory region(s)
UAS
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      parkP21 mutants display a prominent defect in the rapid phase of cytoplasm transfer from the nurse cells to the oocyte during oogenesis. Nurse cells fail to regress and persist until the completion of oogenesis. At the end of oogenesis, the mature egg is a cup-like shape and displays a strong reduction in size.

      (Ottone et al., 2011)

      Homozygotes have an abnormal wing posture phenotype, which increases in frequency with age. The mutant adults also show progressive loss in climbing ability and are shorter lived than normal.

      Mitochondria in the indirect flight muscles of mutant adults have an elongated morphology.

      (Imai et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT suppressed by
      Statement
      Reference

      parkP21 has visible phenotype, non-suppressible by Pgam5NP0568

      (Imai et al., 2010)

      parkP21 has abnormal locomotor behavior phenotype, non-suppressible by Pgam5NP0568

      (Imai et al., 2010)

      parkP21 has short lived phenotype, non-suppressible by Pgam5NP0568

      (Imai et al., 2010)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      parkP21 has mitochondrion phenotype, suppressible by Pgam5NP0568

      (Imai et al., 2010)
      NOT suppressed by
      Statement
      Reference

      parkP21 has wing phenotype, non-suppressible by Pgam5NP0568

      (Imai et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pgam5NP0568 has little effect on the abnormal wing posture phenotype of parkP21 flies, and fails to rescue the progressive loss in climbing ability and reduced lifespan of parkP21 flies.

      Expression of Pgam5Scer\UAS.cIa under the control of Scer\GAL4da.G32 enhances both the progressive loss in climbing ability and reduction in lifespan seen in parkP21 flies.

      The elongated morphology of the mitochondria in the indirect flight muscles of parkP21 adults is suppressed by Pgam5NP0568.

      (Imai et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      parkP21 is rescued by park+tR

      (Ottone et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      parkP21
      parkinP21
      (Imai et al., 2010)
      Name Synonyms
      parkinP21
      (Ottone et al., 2011)
      Secondary FlyBase IDs
        References (3)