FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ple2.UAS
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General Information
Symbol
Dmel\ple2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0249085
Feature type
allele
Associated gene
Dmel\ple
Associated Insertion(s)
Carried in Construct
P{UAS-DTH2}
Also Known As
UAS-DTH2
Key Links
Transgenic product class
wild_type
(Friggi-Grelin et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Friggi-Grelin et al., 2003)
Mutagen
in vitro construct
(Friggi-Grelin et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-DTH2}
Cytology
Description

In the absence of a GAL4 driver, the P{UAS-DTH2} construct shows significant rescue of flies that lack ple function in the central nervous system.

(Cichewicz et al., 2017)

UASt regulatory sequences drive expression of the transcribed region of ple where all exons are present but all intronic regions are removed.

(Friggi-Grelin et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
ple
UASt
Encoded product / tool
ple
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Cichewicz et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of one copy of pleΔ2.Scer\UAS under the control of Scer\GAL4ple.PF results in a wings 'held out' phenotype, where the wings are perpendicular to the body. Two copies of pleΔ2.Scer\UAS results in an exacerbated phenotype, with the wings rigidly held out and folded up in the middle.

      Expression of pleΔ2.Scer\UAS under the control of Scer\GAL4ple.5', Scer\GAL4elav-C155 or Scer\GAL4C1003 does not affect wild-type development.

      (Friggi-Grelin et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4ple.PF/ple2.UAS rescues ple2

      (Friggi-Grelin et al., 2003)

      Scer\GAL4elav-C155/ple2.UAS rescues ple2

      (Friggi-Grelin et al., 2003)

      Scer\GAL4C1003/ple2.UAS rescues ple2

      (Friggi-Grelin et al., 2003)
      Fails to rescue

      Scer\GAL4ple.5'/ple2.UAS fails to rescue ple2

      (Friggi-Grelin et al., 2003)
      Comments

      Expression of pleΔ2.Scer\UAS in DA cells under the control of Scer\GAL4ple.PF leads to full pupal rescue of ple2.

      Neuronal expression of pleΔ2.Scer\UAS under the control of Scer\GAL4elav-C155 or Scer\GAL4C1003 results in significant rescue of ple2 larvae.

      Expression of pleΔ2.Scer\UAS under the control of Scer\GAL4ple.5' does not rescue the embryonic lethality seen in ple2 mutants.

      (Friggi-Grelin et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ple2.UAS
      pleΔ2.Scer\UAS
      pleΔ2.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)