FB2025_01 , released February 20, 2025
Allele: Dmel\edΔC.UAS.GFP
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General Information
Symbol
Dmel\edΔC.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0249393
Feature type
allele
Associated gene
Dmel\ed
Associated Insertion(s)
Carried in Construct
P{UAS-ed.ΔC}
Key Links
Transgenic product class
inframe_deletion
(Laplante and Nilson, 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Laplante and Nilson, 2011)
Mutagen
in vitro construct
(Laplante and Nilson, 2011)
Progenitor genotype
Carried in construct
P{UAS-ed.ΔC}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of ed lacking its cytoplasmic domain except for the first nine amino acids and bearing a C-terminal GFP tag.

(Laplante and Nilson, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ed
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Actomyosin cable formation is the dorsal-most epidermal cells is abolished when edΔC.Scer\UAS.T:Avic\GFP is expressed via Scer\GAL4c381 in the adjacent peripheral amnioserosa cells. These embryos exhibit little or no defect in in the elongation of the more ventral rows of epidermal cells.

      The dorsal-most epidermal cells expressing edΔC.Scer\UAS.T:Avic\GFP via Scer\GAL4prd.RG1 adopt a fan shape with their leading edge splayed wide along the anterior-posterior (AP) axis compared with the narrow leading edge of the wild-type cells. These cells also appear to acquire a migration advantage compared with wild-type cells and they extend further dorsally than their neighbours. In later stages, they establish premature contacts at the dorsal midline.

      (Laplante and Nilson, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      edΔC.Scer\UAS.T:Avic\GFP
      edΔC.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)