FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4GMR18H09
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General Information
Symbol
Scer\GAL4GMR18H09
Species
S. cerevisiae
Name
FlyBase ID
FBal0250344
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR18H09-GAL4}
Also Known As
R18H09
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR18H09-GAL4}
Cytology
Description

A 3332 base pair fragment from the flanking non-coding or intronic region of wb is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR18H09
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult gnathal ganglion | faint | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult mushroom body | faint | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult brain | restricted
      (Shuai et al., 2015)
      mushroom body extrinsic neuron
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 1
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 2
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 4
      (Shuai et al., 2015)
      mushroom body output neuron 5
      (Shuai et al., 2015)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR18H09 drives expression in mushroom body extrinsic neurons, including mushroom body output neuron 5, that innervate mushroom body gamma lobe slices 1, 2 and 4. Expression overlaps with that driven by EcollexAGMR24E12 in mushroom body output neuron 5.

      (Shuai et al., 2015)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4GMR18H09 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, significantly improves 3 hour aversive olfactory memory, compared to controls; this effect is lost when inhibition is restricted to a smaller group of cells using Scer\GAL80R24E12.

      (Shuai et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR18H09
      Name Synonyms
      Secondary FlyBase IDs
        References (5)