FB2026_02 , released June 18, 2026
Allele: Scer\GAL4GMR22C06
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General Information
Symbol
Scer\GAL4GMR22C06
Species
S. cerevisiae
Name
FlyBase ID
FBal0250640
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR22C06-GAL4}
Also Known As
R22C06-Gal4, R22C06
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR22C06-GAL4}
Cytology
Description

A 3034 base pair fragment from the flanking non-coding or intronic region of Wnt2 is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR22C06
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult antennal lobe | faint | restricted
      (Jenett and Svirskas, 2012.9.24)
      lateral antennal lobe tract projection neuron | subset
      (Frank et al., 2015)
      adult medial antennal lobe tract | restricted
      (Frank et al., 2015)
      adult lateral horn | restricted
      (Frank et al., 2015)
      adult mushroom body | restricted
      (Frank et al., 2015)
      posterior lateral protocerebrum | restricted
      (Frank et al., 2015)
      antennal lobe glomerulus VP2
      (Frank et al., 2017)
      antennal lobe glomerulus VP3
      (Frank et al., 2017)
      antennal lobe glomerulus VP4
      (Frank et al., 2017)
      thermosensory projection neuron of adult medial antennal lobe tract
      (Dolan et al., 2019)
      adult neuron | subset of adult ventral nerve cord
      (Jouandet et al., 2023)
      adult taste projection neuron 3
      (Jouandet et al., 2023)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR22C06 drives expression in neurons that arborize within antennal lobe glomerulus VP2, VP3 and VP4.

      (Frank et al., 2017)

      ScerGAL4GMR22C06 drives expression in a subset of hot and cold activated thermosensitive antennal lobe projection neurons. These fasciculate with the medial antennal lobe tract and terminate in the lateral horn, the posterior lateral protocerebrum and mushroom body.

      (Frank et al., 2015)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4GMR22C06 neurons in adults results in a loss of the later stable preference for higher humidity displayed by controls, but does not affect the initial aversion to humid conditions displayed by controls.

      (Frank et al., 2017)

      Silencing Scer\GAL4GMR22C06-expressing neurons produces flies with significant defects in hot and cold avoidance in a two-choice assay.

      (Frank et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR22C06
      Name Synonyms
      Secondary FlyBase IDs
        References (8)