FlyBase Allele Report: Dmel\EndoGI[UAS.cOa]

General Information

Symbol

Dmel\EndoGI^UAS.cOa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of O'Keefe

FlyBase ID

FBal0256910

Feature type

allele

Associated gene

Dmel\EndoGI

Associated Insertion(s)

Carried in Construct

P{UAS-EndoGI.O}

Key Links

Transgenic product class

cDNA

(O'Keefe et al., 2011)

wild_type

(O'Keefe et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(O'Keefe et al., 2011)

wild_type

(O'Keefe et al., 2011)

Mutagen

in vitro construct

(O'Keefe et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-EndoGI.O}

Cytology

Description

UAS regulatory sequences drive expression of EndoGI (derived from the LD25338 cDNA clone).

(O'Keefe et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

EndoGI

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(O'Keefe et al., 2011)

visible, with Scer\GAL4^en-e16E

(O'Keefe et al., 2011)

Phenotype Manifest In

wing | posterior, with Scer\GAL4^en-e16E

(O'Keefe et al., 2011)

wing margin bristle, with Scer\GAL4^ap-md544

(O'Keefe et al., 2011)

wing vein, with Scer\GAL4^en-e16E

(O'Keefe et al., 2011)

Detailed Description

Statement

Reference

Expression of EndoGI^Scer\UAS.cOa under the control of Scer\GAL4^en-e16E results in overgrowth and loss of wing veins in the posterior adult wing.

Expression of EndoGI^Scer\UAS.cOa under the control of Scer\GAL4^ap-md544 results in loss of sensory structures on the dorsal wing margin.

(O'Keefe et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

EndoGI^UAS.cOa, Scer\GAL4^en-e16E has visible phenotype, suppressible | partially by mam²³/mam[+]

(O'Keefe et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

EndoGI^UAS.cOa, Scer\GAL4^en-e16E has wing vein phenotype, suppressible | partially by mam²³/mam[+]

(O'Keefe et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

mam²³/+ partially rescues the loss of wing vein caused by expression of EndoGI^Scer\UAS.cOa under the control of Scer\GAL4^en-e16E.

(O'Keefe et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

EndoGI^UAS.cOa/Scer\GAL4^elav.PLu partially rescues EndoGI^cwk

(O'Keefe et al., 2011)

Comments

Expression of EndoGI^Scer\UAS.cOa under the control of Scer\GAL4^elav.PLu significantly improves the coordination of EndoGI^cwk animals; 73% of females tested can fly. In addition, the motor axon defects seen in EndoGI^cwk embryos are also partially rescued.

(O'Keefe et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EndoGI^Scer\UAS.cOa

EndoGI^UAS.cOa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of O'Keefe

Secondary FlyBase IDs

References (1)

Report Sections

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