FlyBase Allele Report: Dmel\SmE[HMS00074]

General Information

Symbol

Dmel\SmE^HMS00074

Species

D. melanogaster

Name

FlyBase ID

FBal0257105

Feature type

allele

Associated gene

Dmel\SmE

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00074}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00074}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00074

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Hsieh et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^VP16.otu

(Yan and Perrimon, 2015)

lethal, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

lethal | female limited, with Scer\GAL4^dome-PG14

(Yan and Perrimon, 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of SmE^HMS00074 under the control of Scer\GAL4^ninaE.PU does not affect electroretinogram amplitude in 5 day old adults, compared to controls.

(Hsieh et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

SmE^HMS00074, Scer\GAL4^GMR.PU is an enhancer of abnormal size | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Hsieh et al., 2019)

SmE^HMS00074, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Hsieh et al., 2019)

SmE^HMS00074, Scer\GAL4^ninaE.PU is an enhancer of abnormal neurophysiology | adult stage phenotype of Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

SmE^HMS00074, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PU

(Hsieh et al., 2019)

SmE^HMS00074, Scer\GAL4^ninaE.PU is an enhancer of retina phenotype of Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33664

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00074}attP2

NIG-Fly

HMS00074

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00074}attP2

Notes on Origin

Discoverer

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

SmE^HMS00074

(Hsieh et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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