FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PGRP-LCHMS00259
Open Close
General Information
Symbol
Dmel\PGRP-LCHMS00259
Species
D. melanogaster
Name
FlyBase ID
FBal0257160
Feature type
allele
Associated gene
Dmel\PGRP-LC
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00259}
Also Known As
UAS-PGRP-LC RNAi, PGRP-LC-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00259}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00259
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of PGRP-LCHMS00259 under the control of Scer\GAL4Tk.PS leads to fewer enteroendocrine cells and more lipid droplets in the adult anterior midgut.

      (Jugder et al., 2021)

      Adult flies expressing PGRP-LCHMS00259 under the control of Scer\GAL4Act5C.PI exhibit increased susceptibility to Coxiella burnetii: their post-infection survival rate is significantly reduced compared to controls.

      (Bastos et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PGRP-LCHMS00259
      PGRP-LCRNAi
      (Jugder et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)