FlyBase Allele Report: Dmel\Pld[HMS00529]

General Information

Symbol

Dmel\Pld^HMS00529

Species

D. melanogaster

Name

FlyBase ID

FBal0257218

Feature type

allele

Associated gene

Dmel\Pld

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00529}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00529}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00529

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Kankel et al., 2020)

modeled by TBPH^N493D.UAS

(Kankel et al., 2020)

modeled by TBPH^WT.UAS

(Ho et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pld^HMS00529, Scer\GAL4^VGlut1-OK371 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^VGlut1-OK371, TBPH^N493D.UAS

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Pld^HMS00529 is a suppressor | partially of rhabdomere | adult stage phenotype of norpA^P24

(Shieh et al., 2023)

Pld^HMS00529, Scer\GAL4^VGlut1-OK371 is a suppressor | partially of NMJ bouton | larval stage | decreased number phenotype of Scer\GAL4^VGlut1-OK371, TBPH^N493D.UAS

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Pld^HMS00529, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32839

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00529}attP2

NIG-Fly

HMS00529

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00529}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pld^HMS00529

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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