FlyBase Allele Report: Dmel\Prp19[HMS00652]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Prp19^HMS00652

General Information

Symbol

Dmel\Prp19^HMS00652

Species

D. melanogaster

Name

FlyBase ID

FBal0257336

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00652}

Also Known As

UAS-Prp19 RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00652}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of syndromic intellectual disability

CEC

(Li et al., 2024)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Prp19^HMS00652 under the control of Scer\GAL4^Cg.PA leads to tubular and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

Expression of Prp19^HMS00652 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in defective nurse cell chromatin dispersal, and from egg stage 9 onwards, nurse cell nuclei fail to disperse and remain clustered in an interchromatin space, in contrast to wild type.

(Klusza et al., 2013)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Prp19^HMS00652, Scer\GAL4^elav.PU has lethal phenotype, suppressible by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has lethal phenotype, suppressible by Hsap\PRPF19^L499F.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has abnormal behavior | adult stage phenotype, suppressible | partially by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased occurrence of cell division | larval stage phenotype, suppressible by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased occurrence of cell division | larval stage phenotype, suppressible | partially by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased occurrence of cell division | larval stage phenotype, suppressible by Hsap\PRPF19^L499F.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652 has decreased size | larval stage phenotype, suppressible | partially by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased size | larval stage phenotype, suppressible by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased size | larval stage phenotype, suppressible | partially by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased size | larval stage phenotype, suppressible by Hsap\PRPF19^L499F.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has lethal phenotype, suppressible by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

NOT suppressed by

Statement

Reference

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased size | larval stage phenotype, non-suppressible by Hsap\PRPF19^{H273Tfs37.UAS}, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has lethal phenotype, non-suppressible by Hsap\PRPF19^{H273Tfs37.UAS}, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has decreased size | larval stage phenotype, non-suppressible by Iswi^{UAS.RR.Tag:FLAG,Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Other

Statement

Reference

Hsap\PRPF19^G404S.UAS, Prp19^HMS00652, Scer\GAL4^elav.PU has abnormal behavior | adult stage phenotype

(Li et al., 2024)

Hsap\PRPF19^L499F.UAS, Prp19^HMS00652, Scer\GAL4^elav.PU has abnormal behavior | adult stage phenotype

(Li et al., 2024)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Prp19^HMS00652 has vertical lobe of larval mushroom body | larval stage phenotype, non-enhanceable by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Suppressed by

Statement

Reference

Prp19^HMS00652, Scer\GAL4^elav.PU has lobe system of larval mushroom body | larval stage phenotype, suppressible by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has lobe system of larval mushroom body | larval stage phenotype, suppressible by Hsap\PRPF19^L499F.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has larval brain | larval stage phenotype, suppressible by Hsap\PRPF19^UAS.cLa, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has larval brain | larval stage phenotype, suppressible | partially by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has larval brain | larval stage phenotype, suppressible by Hsap\PRPF19^L499F.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has vertical lobe of larval mushroom body | larval stage phenotype, suppressible | partially by Hsap\PRPF19^G404S.UAS, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652 has medial lobe of larval mushroom body | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

NOT suppressed by

Statement

Reference

Prp19^HMS00652, Scer\GAL4^elav.PU has lobe system of larval mushroom body | larval stage phenotype, non-suppressible by Iswi^{UAS.RR.Tag:FLAG,Tag:HA}, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652, Scer\GAL4^elav.PU has lobe system of larval mushroom body | larval stage phenotype, non-suppressible by Hsap\PRPF19^{H273Tfs37.UAS}, Scer\GAL4^elav.PU

(Li et al., 2024)

Prp19^HMS00652 has vertical lobe of larval mushroom body | larval stage phenotype, non-suppressible by Scer\GAL4^elav.PU/Rbfox1^UAS.Unk

(Li et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

32865

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00652}attP2

HMS00652

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00652}attP2

Notes on Origin

Discoverer

Comments

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Prp19^HMS00652

prp19^HMS00652

(Klusza et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections