FlyBase Allele Report: Dmel\slmb[HMS00838]

General Information

Symbol

Dmel\slmb^HMS00838

Species

D. melanogaster

Name

FlyBase ID

FBal0257518

Feature type

allele

Associated gene

Dmel\slmb

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00838}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00838}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00838

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage, with Scer\GAL4^nub.PU

(Reim et al., 2014)

decreased size | adult stage | female limited, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

increased size | adult stage, with Scer\GAL4^ey.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^ey.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^nub.PU

(Reim et al., 2014)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Reim et al., 2014)

karyosome, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

ovary, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

synaptonemal complex | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

wing, with Scer\GAL4^nub.PU

(Reim et al., 2014)

wing sensillum, with Scer\GAL4^nub.PU

(Reim et al., 2014)

Detailed Description

Statement

Reference

The expression of slmb^HMS00838 under the control of Scer\GAL4^VP16.nos.UTR results in small ovaries, with abnormal karyosome morphology and delayed assembly and premature disassembly of the synaptonemal complex.

(Barbosa et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^nub.PU, slmb^HMS00838 has visible | adult stage phenotype, non-suppressible by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^nub.PU

(Reim et al., 2014)

Scer\GAL4^nub.PU, slmb^HMS00838 has decreased size | adult stage phenotype, non-suppressible by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^nub.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has visible | adult stage phenotype, non-suppressible by amls^{RNAi.10xUAS.2-5'UTR}/Scer\GAL4^ey.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has increased size | adult stage phenotype, non-suppressible by amls^{RNAi.10xUAS.2-5'UTR}/Scer\GAL4^ey.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has visible | adult stage phenotype, non-suppressible by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has increased size | adult stage phenotype, non-suppressible by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU

(Reim et al., 2014)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^nub.PU, slmb^HMS00838 has wing phenotype, non-suppressible by amls^{RNAi.10xUAS.3-ORF}/Scer\GAL4^nub.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has eye phenotype, non-suppressible by amls^{RNAi.10xUAS.2-5'UTR}/Scer\GAL4^ey.PU

(Reim et al., 2014)

Scer\GAL4^ey.PU, slmb^HMS00838 has eye phenotype, non-suppressible by amls^UAS.C-Tag:HA/Scer\GAL4^ey.PU

(Reim et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33898

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00838}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

slmb^HMS00838

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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