FlyBase Allele Report: Dmel\Tlk[HMS00943]

General Information

Symbol

Dmel\Tlk^HMS00943

Species

D. melanogaster

Name

FlyBase ID

FBal0257613

Feature type

allele

Associated gene

Dmel\Tlk

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00943}

Also Known As

HMS00943

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00943}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00943

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tlk^HMS00943, Scer\GAL4^da.Switch.PT is a suppressor of decreased cell number | adult stage phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^da.Switch.PT

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^Mhc.F3-580 is a suppressor of visible | adult stage phenotype of Hsap\ASIC2^G430C.UAS, Scer\GAL4^Mhc.F3-580

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^Mhc.F3-580 is a suppressor of increased cell death | adult stage phenotype of Hsap\ASIC2^G430C.UAS, Scer\GAL4^Mhc.F3-580

(Gong and Cheng, 2026)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tlk^HMS00943, Scer\GAL4^da.Switch.PT is a suppressor of dopaminergic PPL1 neuron | adult stage | decreased number phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^da.Switch.PT

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^da.Switch.PT is a suppressor of mitochondrion | adult stage phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^da.Switch.PT

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^da.Switch.PT is a suppressor of adult brain phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^da.Switch.PT

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^Mhc.F3-580 is a suppressor of wing phenotype of Hsap\ASIC2^G430C.UAS, Scer\GAL4^Mhc.F3-580

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^Mhc.F3-580 is a suppressor of indirect flight muscle | adult stage phenotype of Hsap\ASIC2^G430C.UAS, Scer\GAL4^Mhc.F3-580

(Gong and Cheng, 2026)

Tlk^HMS00943, Scer\GAL4^Mhc.F3-580 is a suppressor of mitochondrion | adult stage phenotype of Hsap\ASIC2^G430C.UAS, Scer\GAL4^Mhc.F3-580

(Gong and Cheng, 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33983

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00943}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tlk^HMS00943

tlk^HMS00943

tlk^RNAi-2

(Zhang et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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