FlyBase Allele Report: Scer\GAL4[Mhc.F3-580]

General Information

Symbol

Scer\GAL4^Mhc.F3-580

Species

S. cerevisiae

Name

FlyBase ID

FBal0244763

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{Mhc-GAL4.F3-580}

Also Known As

mhc-GAL4, MhcF3-Gal4, Mhc.F3-580-GAL4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Gajewski and Schulz, 2010)

Progenitor genotype

Carried in construct

P{Mhc-GAL4.F3-580}

Cytology

Description

A 580bp indirect flight muscle specific enhancer region (the "F3-580" fragment) from upstream of Mhc (nucleotides -5165 to -4586 relative to the transcription start site) is fused upstream of sequence encoding a GAL4 driver.

(Gajewski and Schulz, 2010)

Allele components

Component

Use(s)

Regulatory region(s)

Mhc

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

muscle system

(Bloomington Drosophila Stock Center, 2017)

pupal stage P7 -- adult stage

indirect flight muscle cell

(Gajewski and Schulz, 2010)

Additional Information

Statement

Reference

Drives expression in muscle at all developmental stages.

(FlyBase Curators, 2017)

ScerGAL4^Mhc.F3-580 drives expression in the indirect flight muscles from 40 hr APF.

(Gajewski and Schulz, 2010)

Marker for

Reflects expression of

Mhc

(Bloomington Drosophila Stock Center, 2017, Gajewski and Schulz, 2010)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with CNBP^GD7370

(Coni et al., 2021)

abnormal locomotor behavior | adult stage | progressive, with Hsap\ATXN8OS^CTG112.UAS

(Tripathi et al., 2016)

decreased rate of adult locomotory behavior, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

decreased rate of adult locomotory behavior, with Hmgcr^HMC03053

(Al-Sabri et al., 2022)

decreased rate of movement | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

decreased rate of movement | adult stage, with Hmgcr^HMC03053

(Al-Sabri et al., 2022)

increased size | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

short lived, with raptor^HMS00124

(Hatfield et al., 2015)

short lived, with raptor^JF01087

(Hatfield et al., 2015)

short lived, with raptor^JF01088

(Hatfield et al., 2015)

viable, with CNBP^GD7370

(Coni et al., 2021)

viable, with NdufAF3^GD10552

(Murari et al., 2021)

viable, with NdufAF3^HMC03468

(Murari et al., 2021)

viable, with NdufAF4^GD6673

(Murari et al., 2021)

viable, with NdufAF4^HM05053

(Murari et al., 2021)

viable, with NdufAF4^UAS.cMa

(Murari et al., 2021)

visible | adult stage | progressive, with Hsap\ATXN8OS^CTG112.UAS

(Tripathi et al., 2016)

Phenotype Manifest In

indirect flight muscle cell, with Cf2^A40.UAS

(Gajewski and Schulz, 2010)

indirect flight muscle cell, with Cf2^UAS.cMa

(Gajewski and Schulz, 2010)

leg muscle of leg | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

leg muscle of leg | adult stage, with Hmgcr^HMC03053

(Al-Sabri et al., 2022)

mitochondrion | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

mitochondrion | adult stage, with Hmgcr^HMC03053

(Al-Sabri et al., 2022)

myofibril | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

sarcomere | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

wing | progressive, with Hsap\ATXN8OS^CTG112.UAS

(Tripathi et al., 2016)

Z disc | adult stage, with ClC-a^HMC03566

(Al-Sabri et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Suppressor of

Statement

Reference

spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT Suppressor of

Statement

Reference

spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a non-suppressor of visible | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a non-suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Suppressor of

Statement

Reference

spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of wing | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of wing | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT Suppressor of

Statement

Reference

spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a non-suppressor of wing | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38464

w^*; P{Mhc-RFP.F3-580}2, P{Mhc-GAL4.F3-580}2/SM6b

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^Mhc.F3-580

Name Synonyms

Secondary FlyBase IDs

References (26)

Report Sections

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