FB2026_02 , released June 18, 2026
Allele: Dmel\CalpBJF01983
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General Information
Symbol
Dmel\CalpBJF01983
Species
D. melanogaster
Name
FlyBase ID
FBal0219969
Feature type
allele
Associated gene
Dmel\CalpB
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01983}
Also Known As
UAS-CalpB RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01983}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01983
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia 76
      CEA
      (Gan-Or et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing CalpBJF01983 under the control of Scer\GAL4elav.PU display significantly reduced ability to climb compared to the age-matched controls, this climbing defect is more pronounced in 5-day-old than in 1-day-old flies. Axonal defects (axons at neuromuscular junctions are larger than in controls) are observed in CalpBJF01983 expressing larvae.

      (Gan-Or et al., 2016)

      Expression of CalpBJF01983 under the control of Scer\GAL4Mef2.PR (with UAS-Dicer2 to increase RNAi efficiency) does not result in locomotion defects in third instar larvae, while in embryos, the length and width of the lateral transverse muscles is normal.

      (Buffolo et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CalpBJF01983
      CalpBRNAi
      (Metwally et al., 2019)
      CalpainB RNAi25963
      (Gan-Or et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)