FlyBase Allele Report: Dmel\Hsp110[HMS01080]

General Information

Symbol

Dmel\Hsp110^HMS01080

Species

D. melanogaster

Name

FlyBase ID

FBal0257744

Feature type

allele

Associated gene

Dmel\Hsp110

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01080}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01080}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01080

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}, DnaJ-1^UAS.cKb

(Kuo et al., 2013)

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

ameliorates spinocerebellar ataxia 1

modeled by Hsap\ATXN1^82Q.UAS

(Na et al., 2023)

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Na et al., 2023)

exacerbates Creutzfeldt-Jakob disease

modeled by Oari\PrP^VRQ.UAS

(Thackray et al., 2022)

modeled by Hsap\PRNP^M129.UAS.cTa

(Thackray et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsc70Cb^HMS01080 under the control of Scer\GAL4^GMR.PU does not affect eye morphology.

(Kuo et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsp110^HMS01080, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

NOT Suppressor of

Statement

Reference

Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsp110^HMS01080, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

Hsp110^HMS01080, Scer\GAL4^GMR.PU is an enhancer of photoreceptor phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

NOT Suppressor of

Statement

Reference

Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU is a non-suppressor of photoreceptor phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsc70Cb^HMS01080 enhances the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. Eyes have a complete loss of pigment.

Co-expression of Hsc70Cb^HMS01080 and DnaJ-1^Scer\UAS.cKb does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. Complete neuronal degeneration is observed in these flies.

(Kuo et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33742

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01080}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsc70Cb^HMS01080

Hsp110^HMS01080

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close