FlyBase Allele Report: Dmel\Lsm12a[HMS01143]

General Information

Symbol

Dmel\Lsm12a^HMS01143

Species

D. melanogaster

Name

FlyBase ID

FBal0257804

Feature type

allele

Associated gene

Dmel\Lsm12a

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01143}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01143}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01143

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.PE

(Lee et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Lsm12^HMS01143 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4^tim.PE results in significantly longer free-running period (~measured in constant dark conditions) of adult circadian locomotor activity.

(Lee et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Lsm12a^HMS01143, Scer\GAL4^Mz520 is an enhancer of abnormal locomotor rhythm | adult stage phenotype of Scer\GAL4^Mz520, tyf^{ΔC5.UAS.Tag:V5}

(Lee et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The aberrant long-period circadian locomotor rhythm under free-running constant dark conditions characteristic for adult flies expressing tyf^{ΔC5.Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^Mz520 is enhanced by co-expression of Lsm12^HMS01143.

(Lee et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34666