FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\unc-45+t
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General Information
Symbol
Dmel\unc-45+t
Species
D. melanogaster
Name
FlyBase ID
FBal0258022
Feature type
allele
Associated gene
Dmel\unc-45
Associated Insertion(s)
Carried in Construct
P{unc-45+t}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Lee et al., 2011)
wild_type
(Lee et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Lee et al., 2011)
wild_type
(Lee et al., 2011)
Mutagen
in vitro construct
(Lee et al., 2011)
Progenitor genotype
Carried in construct
P{unc-45+t}
Cytology
Description

A unc-45 genomic fragment which includes 654bp upstream of the transcription initiation site and 1154bp downstream of the translation stop codon.

(Lee et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
unc-45
Encoded product / tool
unc-45
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:8,032,948..8,037,658 [+]
Comment:

unc-45 rescue fragment extent determined from reported boundary sequences.

(Lee et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyloidosis
      modeled by Hsap\HTTQ72.ex1p.UAS.EGFP
      (Melkani et al., 2013)
      ameliorates  cardiomyopathy
      modeled by Hsap\HTTQ72.ex1p.UAS.EGFP
      (Melkani et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      unc-45+t is a suppressor | partially of adult heart phenotype of Hsap\HTTQ72.ex1p.UAS.EGFP, Scer\GAL4HCH.Hand

      (Melkani et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of unc-45+t significantly reduces cardiac dysfunction of 3 week old flies expressing Hsap\HTTQ72.ex1p.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4HCH.Hand. The defects in systolic diameter, diastolic diameter, systolic interval, fractional shortening and cardiac arrhythmia are all significantly suppressed. The density of Hsap\HTTQ72.ex1p.Scer\UAS.T:Avic\GFP-EGFP protein aggregates is also significantly reduced while the average size of the aggregates is unchanged.

      (Melkani et al., 2013)
      Complementation and Rescue Data
      Rescues

      unc-45+t rescues unc-45EY03034-33

      (Lee et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      unc-45+t
      Name Synonyms
      Secondary FlyBase IDs
        References (3)