FlyBase Allele Report: Dmel\TER94[K2A.UAS]

General Information

Symbol

Dmel\TER94^K2A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0258036

Feature type

allele

Associated gene

Dmel\TER94

Associated Insertion(s)

Carried in Construct

P{UAS-TER94.K2A.C}

Also Known As

UAS-TER94^K2A

Key Links

Transgenic product class

missense_variant

(Chang et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Chang et al., 2011)

Mutagen

in vitro construct

(Chang et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-TER94.K2A.C}

Cytology

Description

UAS regulatory sequences drive expression of a K248A-K521A double mutant of TER94.

(Chang et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

TER94

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ninaE.PT

(Chang et al., 2011)

lethal, with Scer\GAL4^bam.PU

(Butsch et al., 2023)

lethal | larval stage

(Chang et al., 2011)

lethal | P-stage

(Chang et al., 2011)

Phenotype Manifest In

muscle cell | embryonic stage, with Scer\GAL4^how-24B

(Chang et al., 2011)

outer photoreceptor cell, with Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Detailed Description

Statement

Reference

Developing muscle fibers are completely absent in embryos expressing TER94^K2A.Scer\UAS under the control of Scer\GAL4^how-24B.

Flies expressing TER94^K2A.Scer\UAS under the control of Scer\GAL4^Mhc.PW show impaired flight.

Animals overexpressing TER94^K2A.Scer\UAS under the control of Scer\GAL4^GMR.PF die at larval or early pupal stage.

Animals co-expressing TER94^K2A.Scer\UAS and TER94^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF survive.

Expression of TER94^K2A.Scer\UAS under the control of Scer\GAL4^ninaE.PT induces outer photoreceptor cell degradation. Constant darkness does not mitigate this phenotype.

(Chang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has abnormal neuroanatomy phenotype, non-enhanceable by PTPMT1^GD4965, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has abnormal neuroanatomy phenotype, non-enhanceable by PTPMT1^KK108325, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has abnormal neuroanatomy phenotype, non-suppressible by PTPMT1^GD4965, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has abnormal neuroanatomy phenotype, non-suppressible by PTPMT1^KK108325, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has outer photoreceptor cell phenotype, non-enhanceable by PTPMT1^GD4965, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has outer photoreceptor cell phenotype, non-enhanceable by PTPMT1^KK108325, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has outer photoreceptor cell phenotype, non-suppressible by PTPMT1^GD4965, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Scer\GAL4^ninaE.PT, TER94^K2A.UAS has outer photoreceptor cell phenotype, non-suppressible by PTPMT1^KK108325, Scer\GAL4^ninaE.PT

(Chang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Plip^GD4965 under the control of Scer\GAL4^ninaE.PT has no significant effect on TER94^K2A.Scer\UAS-induced photoreceptor cell degradation.

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT has no significant effect on TER94^K2A.Scer\UAS-induced photoreceptor cell degradation.

(Chang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

TER94^K2A.Scer\UAS

TER94^K2A.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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