FlyBase Allele Report: Dmel\Sik2[K170M.UAS.Tag:MYC]

General Information

Symbol

Dmel\Sik2^{K170M.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0258123

Feature type

allele

Associated gene

Dmel\Sik2

Associated Insertion(s)

Carried in Construct

P{UAS-SIK2-Myc.K1701M}

Key Links

Transgenic product class

missense_variant

(Choi et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Choi et al., 2011)

Mutagen

in vitro construct

(Choi et al., 2011)

Progenitor genotype

Sik2^UAS.Tag:MYC

(Choi et al., 2011)

Carried in construct

P{UAS-SIK2-Myc.K1701M}

Cytology

Description

Amino acid replacement: K170M.

(Choi et al., 2011)

UASt regulatory sequences drive expression of kinase-dead Sik2 coding sequences.

(Choi et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Sik2

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Detailed Description

Statement

Reference

Expression of SIK2^{K170M.Scer\UAS.T:Hsap\MYC} in the developing eye under the control of Scer\GAL4^GMR.PF does not generate any apparent phenotype.

(Choi et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC}, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Delta^UAS.cJa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, Ser^KK108416

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, Ser^KK108416

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa

(Şahin et al., 2020)

Other

Statement

Reference

Delta^UAS.cJa, Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC} has visible | adult stage phenotype

(Şahin et al., 2020)

Delta^UAS.cJa, Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC}, lola^GS88A8 has visible | adult stage phenotype

(Şahin et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC}, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Delta^UAS.cJa, Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, Ser^KK108416

(Şahin et al., 2020)

Sik2^{K170M.UAS.Tag:MYC}/Scer\GAL4^GMR.long, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Scer\GAL4^ey.PH, fng^UAS.cKa

(Şahin et al., 2020)

NOT Suppressor of

Statement

Reference

Sik2^{K170M.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Crtc^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Choi et al., 2011)

Sik2^{K170M.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is a non-suppressor of ommatidium phenotype of Crtc^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Choi et al., 2011)

Sik2^{K170M.UAS.Tag:MYC}, Scer\GAL4^GMR.PF is a non-suppressor of interommatidial bristle phenotype of Crtc^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Choi et al., 2011)

Other

Statement

Reference

Delta^UAS.cJa, Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC} has eye phenotype

(Şahin et al., 2020)

Delta^UAS.cJa, Scer\GAL4^ey.PH, Sik2^{K170M.UAS.Tag:MYC}, lola^GS88A8 has eye phenotype

(Şahin et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of SIK2^{K170M.Scer\UAS.T:Hsap\MYC} with TORC^{Scer\UAS.T:Zzzz\FLAG} in the developing eye, both under the control of Scer\GAL4^GMR.PF, has no effect on the TORC^{Scer\UAS.T:Zzzz\FLAG}-induced rough eye phenotype.

(Choi et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

SIK2^{K170M.Scer\UAS.T:Hsap\MYC}

Sik2^{K170M.Scer\UAS.T:Hsap\MYC}

Sik2^{K170M.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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